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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 140 kDa
物種活性
rat, mouse, canine
技術
immunoprecipitation (IP): 10-20 μg using rat brain extract (S1 fraction)
indirect immunofluorescence: 10-20 using MDCK cells.
microarray: suitable
western blot: 1-2 μg/mL using mouse and rat brain extracts (S1 fraction)
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... PPP1R9B(84687)
mouse ... Ppp1r9b(217124)
rat ... Ppp1r9b(84686)
一般說明
Neurabin II belongs to a family of F-actin-binding proteins, highly enriched in dendritic spines and involved in neurite formation. It consists of an F-actin binding domain at the N-terminus, a single PDZ-interacting-domain and a C-terminal coiled-coil domain.
免疫原
synthetic peptide corresponding to amino acids 800-817 located at the C-terminal region of rat neurabin II. The sequence is identical in human and mouse neurabin II and not found in neurabin I.
應用
Anti-Neurabin II (C-terminal) antibody has been used in
- immunoblotting
- immunoprecipitation
- immunocytochemistry
生化／生理作用
Neurabins appear to function as bridging proteins by targeting other proteins to the synapse or by linking plasma membrane proteins to the actin cytoskeleton. Neurabin II binds to several proteins including F-actin, protein phosphatase 1 (PP1), at least two subfamilies of G-protein coupled receptors (GPCRs), the α2 adrenergic receptor (α2AR) subtypes and the D2 dopamine receptor. Neurabin II blocks arrestin function in vitro and in vivo at GPCRs and has been also shown to modulate, in vitro and in vivo, both glutaminergic synaptic transmission and the formation and function of dendritic spines. Neurabin II and neurabin I target PP1 subunits that are highly concentrated in dendritic spines and post-synaptic densities. Phosphorylation of neurabin II modulates its interaction with actin filaments, via the anchoring of the neurabin II-PP1 complex within dendritic spines, thereby contributing to the efficacy and plasticity of synaptic transmission.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits
Terry-Lorenzo R T, et al.
Test, 277(31), 27716-27724 (2002)
Neurabin-II/spinophilin an actin filament-binding protein with one pdz domain localized at cadherin-based cell-cell adhesion sites
Satoh A, et al.
The Journal of Biological Chemistry, 273(6), 3470-3475 (1998)
Different behavior of l-afadin and neurabin-II during the formation and destruction of cell-cell adherens junction
Sakisaka T, et al.
Oncogene, 18(8), 1609-1609 (1999)
The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein
Vivo M, et al.
Test, 276(17), 14161-14169 (2001)
Reduced dendritic spine density in auditory cortex of subjects with schizophrenia
Sweet R A, et al.
Neuropsychopharmacology, 34(2), 374-374 (2009)
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