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Merck
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文件

N4766

Sigma-Aldrich

N-亚硝基-N-甲基脲

Bulk package

别名:

MNU, N-甲基-N-亚硝基脲

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About This Item

经验公式（希尔记法）:
C2H5N3O2
CAS号:
684-93-5
分子量:
103.08
MDL號碼:
MFCD00014794
分類程式碼代碼:
12352200
PubChem物質ID:
24897712

形狀

solid

包含

aqueous acetic acid as stabilizer

儲存溫度

2-8°C

SMILES 字串

CN(N=O)C(N)=O

InChI

1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6)

InChI 密鑰

ZRKWMRDKSOPRRS-UHFFFAOYSA-N

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生化／生理作用

一种在许多动物物种中具有致癌性的DNA烷基化剂。 尽管MNU可以在大多数器官中诱发良性和恶性肿瘤，但它最常用于模拟乳腺肿瘤的发生和发展。

包裝

Weight on dry basis.

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Carc. 1B - Flam. Sol. 2 - Repr. 1B

儲存類別代碼

4.1B - Flammable solid hazardous materials

水污染物質分類（WGK）

WGK 1

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges

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Marzena Kurowska et al.
Mutation research, 738-739, 52-70 (2012-10-23)
We present studies aimed at determining the types and frequencies of mutations induced in the barley genome after treatment with chemical (N-methyl-N-nitrosourea, MNU) and physical (gamma rays) mutagens. We created M(2) populations of a doubled haploid line and used them
Yuan-Yuan Chen et al.
Experimental eye research, 121, 102-113 (2014-02-11)
Mouse retinal degeneration models have been investigated for many years in the hope of understanding the mechanism of photoreceptor cell death. N -methyl- N -nitrosourea (MNU) has been previously shown to induce outer retinal degeneration in mice. After MNU was
Kawiya Sintara et al.
Journal of biomedicine & biotechnology, 2012, 915380-915380 (2012-06-13)
To determine effects of curcumin on N-methyl-N-nitrosourea (MNU) and saturated sodium chloride (s-NaCl)-induced gastric cancer in rats. Male Wistar rats were divided into 5 groups: control (CO), control supplemented with 200 mg/kg curcumin (CC), MNU + s-NaCl, MNU + s-NaCl supplemented with 200 mg/kg curcumin daily
Yong Soon Chun et al.
Carcinogenesis, 33(11), 2242-2249 (2012-07-27)
Multiple lines of evidence support a role for curcumin in cancer chemoprevention. Nonetheless, despite its reported efficacy and safety profile, clinical translation of curcumin has been hampered by low oral bioavailability, requiring infeasible 'mega' doses for achieving detectable tissue levels.
Weiqin Jiang et al.
Cancer research, 72(15), 3795-3806 (2012-06-02)
An increased ratio of dietary n-3 relative to n-6 fatty acids has been shown to inhibit the development of mammary cancer in animal models. However, the molecular mechanisms by which n-3 fatty acids affect tumor growth remain unknown. Here, we
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