MAK324

Acetylcholinesterase Inhibitor Screening Kit

sufficient for 100 colorimetric tests

• 别名: AChE Inhibitor Assay Kit
• 分類程式碼代碼: 12161503
• NACRES: NA.84

属性

• 用途: sufficient for 100 colorimetric tests
• 檢測方法: colorimetric
• 相關疾病: neurological disorders, Alzheimer′s disease
• 儲存溫度: −20°C

说明

一般說明

Acetylcholinesterase (AChE), also known as RBC cholinesterase, is found primarily in the blood and neural synapses. AChE catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. Inhibition of the enzyme leads to acetylcholine accumulation, hyperstimulation of nicotinic and muscarinic receptors, and disrupted neurotransmission. AChE inhibition is an important target for the management of Alzheimer′s disease and AChE inhibitors are the most common drugs used for its management. In addition to Alzheimer′s disease, AChE inhibitors have been useful in the diagnosis or treatment of diseases such as glaucoma, myasthenia gravis, bladder distention, and more. The Acetylcholinesterase Inhibitor Screening kit is based on an improved Ellman method, in which thiocholine produced by the action of acetylcholinesterase forms a yellow color with 5,5′-dithiobis(2-nitrobenzoic acid). The intensity of the product color, measured at 412 nm, is proportionate to the enzyme activity in the sample.

應用

• In vitro assessment of selected Korean plants for antioxidant and antiacetylcholinesterase activities.: This research evaluates the antioxidant and anti-acetylcholinesterase activities of various Korean plants using in vitro screening, showcasing the screening kit′s application in natural product research (Lee et al., 2017).

The Acetylcholinesterase Inhibitor Screening Kit may be used for:

• Drug Discovery
• Neurological Disease Research
• Alzheimer′s Disease Research

特點和優勢

Efficient Inhibitor Screening: Screen for AChE inhibitors with only 5 μL of test compound and a short 15 minute reaction time, offering a streamlined and effortless procedure.

Compatibility with High-Throughput Systems: Easily incorporate our kit into high-throughput handling systems, ensuring smooth and accurate processing, enhancing efficiency in your laboratory workflow.

適合性

Suitable for inhibitor screening and evaluation of acetylcholinesterase inhibitors.

其他說明

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安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3