MAK155

鞘磷脂酶检测试剂盒（荧光法）

sufficient for 200 fluorometric tests (red fluorescence)

• 别名: 中性鞘磷脂酶检测试剂盒
• 分類程式碼代碼: 12161503
• NACRES: NA.84

属性

• 用途: sufficient for 200 fluorometric tests (red fluorescence)
• 檢測方法: fluorometric
• 相關疾病: cancer; rheumatological diseases
• 儲存溫度: −20°C
• 基因資訊: human ... SMPD2(6610) , SMPD3(55512) , SMPD4(55627) ; mouse ... SMPD2(20598) , SMPD3(58994) , SMPD4(77626) ; rat ... SMPD2(83537) , SMPD3(94338) , SMPD4(303790)

说明

一般說明

Sphingomyelinase (SMase), or sphingomyelin phosphodiesterase, catalyzes the hydrolytic cleavage of sphingolipid to phosphocholine and ceramide, a second messenger involved in multiple cellular responses including the cellular response to stress. There are at least five types of SMases identified, which are classified according to their cation dependence, cellular location, and pH optima for activity, and include the acidic and neutral sphingomyelinase. Neutral SMases, along with the acidic SMases, are thought to be major contributors to the production of ceramide in response to cellular stress. Mutations in is associated with metabolic disorders like Niemann-Pick disease B.

適合性

本试剂盒适于检测多种样品中的鞘磷脂，如血液及细胞提取物等。

原則

The Sphingomyelinase Assay Kit provides a simple and direct procedure for measuring neutral SMase activity in a variety of samples such as blood or cell extracts, or for screening SMase activators and inhibitors. SMase activity is determined by a coupled enzyme assay, which results in a fluorescent product (λex =540/λem = 590 nm) proportional to the SMase activity present.

安全信息

• 象形圖: GHS08,GHS05,GHS07,GHS09
• 訊號詞: Danger
• 危險聲明: H302,H317,H318,H334,H410
• 防範說明: P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Sens. 1
• 儲存類別代碼: 10 - Combustible liquids