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Merck

M7133

Sigma-Aldrich

4-甲基伞形酮硫酸盐 钾盐

sulfatase substrate

别名:

4-甲基伞形基硫酸钾

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About This Item

经验公式(希尔记法):
C10H7KO6S
CAS号:
分子量:
294.32
Beilstein:
3803203
EC號碼:
MDL號碼:
分類程式碼代碼:
12352204
PubChem物質ID:
NACRES:
NA.32

化驗

≥99% (HPLC)

形狀

powder

溶解度

water: 5 mg/mL, clear, colorless

螢光

λex 334 nm; λem 370 nm (pH 10.4)
λex 360 nm; λem 449 nm (Reaction products)

儲存溫度

−20°C

SMILES 字串

[K+].CC1=CC(=O)Oc2cc(OS([O-])(=O)=O)ccc12

InChI

1S/C10H8O6S.K/c1-6-4-10(11)15-9-5-7(2-3-8(6)9)16-17(12,13)14;/h2-5H,1H3,(H,12,13,14);/q;+1/p-1

InChI 密鑰

CSOCSPXOODWGLJ-UHFFFAOYSA-M

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一般說明

4-甲基伞形酮硫酸酯(4MUS)作为一种通用底物,是4-甲基伞形酮(4MU)的极性代谢物。

應用

4-甲基伞形酮硫酸酯钾盐已用作偶联荧光硫代转移酶测定的底物,以从3′-磷酸腺苷5′-磷酸盐再生3′-磷酸腺苷 5′-磷酸硫酸盐(PAPS),进而测定脑苷脂硫酸转移酶(CST)的酶活性。它还用作芳香基硫酸酯酶测定/4-甲基伞形酮硫酸酯(4-MUS)测定的底物,以测试蛋白磁珠复合体的酶活性。

生化/生理作用

4-甲基伞形酮硫酸酯(4MUS)能够进行脱硫,并参与4MU的无效循环。它可以用于测定多种硫酸酯酶的活性。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Junichi Enokizono et al.
Drug metabolism and disposition: the biological fate of chemicals, 35(6), 922-928 (2007-03-14)
Breast cancer resistance protein (Bcrp/Abcg2) is a member of the ATP-binding cassette transporter family with the ability to transport a variety of sulfate conjugates. In the present study, the regional expression and activity of Bcrp and sulfotransferases (SULTs/Sults) were investigated
Anthony D Verderosa et al.
Scientific reports, 11(1), 1569-1569 (2021-01-17)
Antibiotics are failing fast, and the development pipeline remains alarmingly dry. New drug research and development is being urged by world health officials, with new antibacterials against multidrug-resistant Gram-negative pathogens as the highest priority. Antivirulence drugs, which inhibit bacterial pathogenicity
Lihua Wang-Eckhardt et al.
Cells, 10(12) (2021-12-25)
Sulfatide synthesis in the human renal cancer cell line SMKT-R3 was strongly inhibited in the presence of low µM concentrations of AG-205, a progesterone receptor membrane component 1 (PGRMC1) antagonist. This was also the case in Chinese hamster ovary (CHO)
P M Edelbroek et al.
Journal of chromatography, 530(2), 347-358 (1990-09-14)
The anticoagulant phenprocoumon is mainly metabolized in humans to hydroxylated metabolites and their glucuronides. A method is described for the determination of phenprocoumon, 4'-hydroxyphenprocoumon, 6-hydroxyphenprocoumon, 7-hydroxyphenprocoumon, and their glucuronide and sulphate conjugates in human urine. Reversed-phase high-performance liquid chromatography is
O P van Diggelen et al.
Journal of inherited metabolic disease, 12(3), 273-280 (1989-01-01)
Arylsulphatase C (ASC) activity in leukocytes and fibroblasts measured with 4-methylumbelliferylsulphate, is caused by at least two genetically different sulphatases. One of these is steroid sulphatase (STS). Depending on the substrate concentration, about 10-50% of the ASC activity in leukocytes

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Drug conjugate analysis and the enzymatic hydrolysis of glucuronides

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