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生物源
mouse
共軛
unconjugated
抗體表格
ascites fluid
抗體產品種類
primary antibodies
無性繁殖
FA-24, monoclonal
包含
15 mM sodium azide
技術
indirect ELISA: 1:5,000
同型
IgG2b
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
一般說明
Monoclonal Anti-5MTH Folic Acid antibody is specific for an epitope present on 5MTHFA and does not detect folic acid. This hybridoma is a cloned cell line derived from a fusion between a mouse myeloma cell line and splenocytes from BALB/c mice immunized with 5MTH Folic acid conjugated to KLH.
免疫原
5MTH folic acid, conjugated to KLH.
應用
Monoclonal Anti-5MTH Folic Acid antibody is suitable for use in indirect (Enzyme Linked Immuno Sorbent Assay) ELISA (1:5,000) and competitive ELISA.
Monoclonal Anti-5MTH Folic Acid antibody is suitable for use in indirect ELISA (1:5,000).
生化／生理作用
5-Methyltetrahydrofolate (5-MTHF) is a cofactor that regulates the conversion of homocysteine to methionine in the presence of another co-factor, vitamin B12. 5-MTHF is also involved in modulating antioxidative and cognitive functions. Increased serum 5-MTHF levels have been linked to anemia and macrocytosis. The antibody reacts with 5MTHFA as a free reagent or when conjugated to carriers such as KLH or BSA. Furthermore, the product associates with 5MTHFA bound to the endogenous folate binder in human plasma and serum. The monoclonal antibody does not cross-react with tetrahydrofolic acid, folinic acid, dihydrofolic acid, and vitamin B12.
Vitamin B12 and folic acid are metabolically interrelated. The enzyme methionine synthetase, which catalyzes the conversion of homocysteine to methionine, requires vitamin B12 and 5MTHFA as cofactors. In the absence of vitamin B12, 5MTHFA cannot be converted to tetra hydro folic acid and enter the metabolic pool of 1-carbon fragment acceptors. Vitamin B12 and folate deficiencies are the most common causes of megaloblastic anemia, abnormal hemopoiesis, interference in the maintenance of normal nerve tissue and general intracellular uptake and function disorders in humans. Folic acid deficiency is common in pregnant women, alcoholics, those whose diets do not include raw fruits and vegetables and people with structural or functional damage to the small intestine.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Martha Savaria Morris et al.
The American journal of clinical nutrition, 91(6), 1733-1744 (2010-04-02)
Folate deficiency has serious consequences for the fetus. Folic acid fortification of food addresses this problem. However, clinical consequences of vitamin B-12 deficiency may be worsened by high folic acid intakes, perhaps as a direct result of unmetabolized folic acid
Bashir M Rezk et al.
FEBS letters, 555(3), 601-605 (2003-12-17)
The presumed protective effect of folic acid on the pathogenesis of cardiovascular, hematological and neurological diseases and cancer has been associated with the antioxidant activity of folic acid. Peroxynitrite (PON) scavenging activity and inhibition of lipid peroxidation (LPO) of the
Folic acid deficiency and cancer: mechanisms of DNA instability
Duthie S J.
British Medical Bulletin, 55(3), 578-592 (1999)
Intestinal absorption of folic acid - new physiologic & molecular aspects
Milman, N.
The Indian Journal of Medical Research, 136(5), 725-725 (2012)
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