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Merck
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M4796

Sigma-Aldrich

(±)-α-Methyl-(4-carboxyphenyl)glycine

别名:

(±)-MCPG

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About This Item

经验公式（希尔记法）:
C10H11NO4
CAS号:
146669-29-6
分子量:
209.20
MDL编号:
MFCD00210205
UNSPSC代码:
12352200
PubChem化学物质编号:
24278286
NACRES:
NA.77

SMILES字符串

CC(N)(C(O)=O)c1ccc(cc1)C(O)=O

InChI

1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)

InChI key

DNCAZYRLRMTVSF-UHFFFAOYSA-N

基因信息

human ... GRM1(2911) , GRM2(2912) , GRM3(2913) , GRM5(2915)
rat ... Grm1(24414)

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生化/生理作用

Competitive antagonist at Group 1 (mGluR1 and mGluR5) and Group 2 (mGluR2 and mGluR3) metabotropic glutamate receptors.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
027K3795
096H3788
044K3795
096H37881

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Hilary Gerstein et al.
Neurobiology of learning and memory, 97(1), 17-29 (2011-09-29)
Homer1 belongs to a family of scaffolding proteins that interact with various post-synaptic density proteins including group I metabotropic glutamate receptors (mGluR1/5). Previous research in our laboratory implicates the Homer1c isoform in spatial learning. Homer1 knockout mice (H1-KO) display cognitive
D D Schoepp et al.
Neuropharmacology, 36(1), 1-11 (1997-01-01)
The novel compound LY354740 is a conformationally constrained analog of glutamate, which was designed for interaction at metabotropic glutamate (mGlu) receptors. In this paper the selectivity of LY354740 for recombinant human mGlu receptor subtypes expressed in non-neuronal (RGT) cells is
Ana C Takakura et al.
Experimental physiology, 96(10), 989-999 (2011-07-12)
In the present study, we evaluated the role of glutamatergic mechanisms in the retrotrapezoid nucleus (RTN) in changes of splanchnic sympathetic nerve discharge (sSND) and phrenic nerve discharge (PND) elicited by central and peripheral chemoreceptor activation. Mean arterial pressure (MAP)
L S Thomas et al.
Neuropharmacology, 39(9), 1554-1566 (2000-06-16)
In the present study we have examined the role of presynaptic group I metabotropic glutamate (mGlu) receptors in the control of neuronal glutamate release using rat forebrain slices pre-loaded with [(3)H]D-aspartate. We have also addressed the question of which group
K M Huber et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(1), 1-9 (1998-01-24)
The neurotransmitter glutamate, in addition to activating ligand-gated ion channels, also stimulates phosphoinositide (PI) hydrolysis in neurons by activating a group of G-protein-coupled metabotropic glutamate receptors (mGluRs). A role for mGluRs in synaptic plasticity originally was hypothesized based on the
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