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化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white to off-white
溶解度
DMSO: ≥10 mg/mL
起源
Merck & Co., Inc., Kenilworth, NJ, U.S.
儲存溫度
room temp
SMILES 字串
COc1ccc(cc1)C2=Cc3onc(-c4ccncc4)c3C(=O)N2C
InChI
1S/C19H15N3O3/c1-22-15(12-3-5-14(24-2)6-4-12)11-16-17(19(22)23)18(21-25-16)13-7-9-20-10-8-13/h3-11H,1-2H3
InChI 密鑰
PDWYBOZNEVALOV-UHFFFAOYSA-N
生化／生理作用
MMPIP is a potent, selective, allosteric antagonist of metabotropic glutamate receptor 7 (mGluR7). It also displays intrinsic activity and acts as an inverse agonist.
特點和優勢
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Juan Du et al.
Nature, 594(7864), 589-593 (2021-06-18)
The metabotropic glutamate receptors (mGlus) are involved in the modulation of synaptic transmission and neuronal excitability in the central nervous system1. These receptors probably exist as both homo- and heterodimers that have unique pharmacological and functional properties2-4. Here we report
Paulina Cieślik et al.
Frontiers in molecular neuroscience, 11, 316-316 (2018-10-09)
The data concerning antipsychotic-like activity of negative allosteric modulators (NAMs)/antagonists of mGlu7 receptors are limited. The only available ligands for this receptor are MMPIP and ADX71743. In the present studies, we used stable cell line expressing mGlu7 receptor and it
Sinead E Shortall et al.
Molecular neurobiology, 57(8), 3439-3457 (2020-06-14)
Despite several compounds entering clinical trials for the negative and cognitive symptoms of schizophrenia, few have progressed beyond phase III. This is partly attributed to a need for improved preclinical models, to understand disease and enable predictive evaluation of novel
Jolanta H Kotlinska et al.
European journal of pharmacology, 858, 172512-172512 (2019-07-02)
The present study was conducted to evaluate the influence of AMN082, the metabotropic glutamate receptor subtype 7 (mGlu7) allosteric agonist on different stages of memory processes connected with fear conditioning in the passive avoidance (PA) learning task in mice and
George A Lemieux et al.
PLoS biology, 11(11), e1001712-e1001712 (2013-11-22)
Phenotypic screens can identify molecules that are at once penetrant and active on the integrated circuitry of a whole cell or organism. These advantages are offset by the need to identify the targets underlying the phenotypes. Additionally, logistical considerations limit
商品
Sigma-Aldrich offers many products related to G-protein family glutamate receptors for your research needs.
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