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生物源
Larix kaempferi
化驗
≥98% (HPLC)
形狀
powder or crystals
儲存條件
protect from light
顏色
white to off-white
溶解度
methanol: 1 mg/mL, clear, colorless
應用
metabolomics
vitamins, nutraceuticals, and natural products
儲存溫度
2-8°C
SMILES 字串
O=C(OC)C1=CC[C@@]2(C(O[C@@](/C=C/C=C(C(O)=O)\C)(C)[C@@H]3CC2)=O)[C@]3(OC(C)=O)CC1
InChI
1S/C23H28O8/c1-14(17(24)25)6-5-10-21(2)16-9-12-22(19(27)31-21)11-7-15(18(26)29-3)8-13-23(16,22)20(28)30-4/h5-7,10,16H,8-9,11-13H2,1-4H3,(H,24,25)/b10-5+,14-6+/t16-,21+,22+,23+/m0/s1
InChI 密鑰
XRLYZNSOXNPKOR-CBDALDGHSA-N
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生化／生理作用
土槿皮中分离得到天然二萜类化合物土槿皮乙酸B。它已显示出抗真菌，抗生育和抗血管生成特性。它还可能具有抗癌和抗炎特性。
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral - Repr. 2
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Pauline Chiu et al.
Natural product reports, 27(7), 1066-1083 (2010-04-21)
The pseudolaric acids are diterpenoids isolated from the root bark of Pseudolarix amabilis, or the golden larch. Pseudolaric acids A and B are the major antifungal and anti-angiogenic congeners of this family of compounds. This review presents the results of
Peng Liu et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 46(11), 1361-1365 (2012-01-21)
The metabolic profile of pseudolaric acid B (PB) was investigated by using in vivo and in vitro tests. Pseudolaric acid C2 (PC2) was identified as the specific metabolite of PB in plasma, urine, bile and feces using HPLC and HPLC-ESI/MS(n)
Dandan Zhao et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(4), 595-602 (2012-03-06)
Pseudolaric acid B (PAB), a natural diterpene acid present in the traditional Chinese medicinal herb Tu-Jin-Pi, exerted anticancer effects on various cancer cells. However, the effect of PAB on DU145 cells, an in vitro model of hormone-refractory prostate cancer (HRPC)
Jinghua Yu et al.
Journal of pharmacological sciences, 107(3), 295-302 (2008-07-19)
Pseudolaric acid B (PAB) exerted cytostatic activity on murine fibrosarcoma L929 cells. The cytostatic mechanism of PAB on L929 cells was investigated in this paper. At 36 h, after 80 microM PAB treatment, the inhibitory ratio was 65.37 +/- 4.12%
Tan Li et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 45(5), 668-676 (2012-01-24)
Pseudolaric acid B (PAB) is a novel diterpenoid, isolated from Pseudolarix kaempferi Gorden, which roots are widely used to treat inflammatory and microbial skin diseases for centuries, but the underlying mechanism remains elusive. To address the immunoregulatory mechanisms of PAB
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