推荐产品
化驗
≥95% (HPLC)
品質等級
形狀
film
溶解度
DMSO: soluble 25 mg/mL
儲存溫度
−20°C
SMILES 字串
[H][C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2C)[C@@H](O)C(C)C
InChI
1S/C10H15NO4/c1-4(2)6(12)10-7(15-9(10)14)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10-/m1/s1
InChI 密鑰
FWPWHHUJACGNMZ-NBBQQVJHSA-N
應用
Clasto-乳胞素 β-内酯用作蛋白酶体抑制剂。
Clasto-乳胞素β-内酯已用作蛋白降解抑制剂以检测其对小鼠记忆改善的作用。它还用作人卵巢上皮(HOSE)细胞和树突状细胞(DC)的蛋白酶体抑制剂。
生化／生理作用
Clasto-乳胞素β-内酯(cLβL)由乳胞素(Lactacystin)合成。它具有细胞可透过性。cLβL可作用于蛋白酶体β -亚基X的N端苏氨酸。还可通过作用于β -型亚基的N-苏氨酸残基，抑制嗜盐古菌Haloferax volcanii的20S蛋白酶体活性。
细胞渗透性和不可逆蛋白酶体抑制剂。乳胞素作为染色体断裂-乳胞素 β 的前体-内酯。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Sue-Hyun Lee et al.
Science (New York, N.Y.), 319(5867), 1253-1256 (2008-02-09)
Reactivated memory undergoes a rebuilding process that depends on de novo protein synthesis. This suggests that retrieval is dynamic and serves to incorporate new information into preexisting memories. However, little is known about whether or not protein degradation is involved
L R Dick et al.
The Journal of biological chemistry, 272(1), 182-188 (1997-01-03)
The natural product lactacystin exerts its cellular antiproliferative effects through a mechanism involving acylation and inhibition of the proteasome, a cytosolic proteinase complex that is an essential component of the ubiquitin-proteasome pathway for intracellular protein degradation. In vitro, lactacystin does
Timothy J Jarome et al.
PloS one, 6(9), e24349-e24349 (2011-10-01)
Protein degradation through the ubiquitin-proteasome system [UPS] plays a critical role in some forms of synaptic plasticity. However, its role in memory formation in the amygdala, a site critical for the formation of fear memories, currently remains unknown. Here we
Kristen Willeumier et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(44), 11333-11341 (2006-11-03)
The ubiquitin proteasome system, generally known for its function in protein degradation, also appears to play an important role in regulating membrane trafficking. A role for the proteasome in regulating presynaptic release and vesicle trafficking has been proposed for invertebrates
Coordinated regulation of dendrite arborization by epigenetic factors CDYL and EZH2
Qi C, et al.
The Journal of Neuroscience, 34(13), 4494-4508 (2014)
商品
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门