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Merck

L2654

Sigma-Aldrich

脂多糖 来源于大肠杆菌 026:B6

γ-irradiated, BioXtra, suitable for cell culture

别名:

LPS

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About This Item

EC號碼:
MDL號碼:
分類程式碼代碼:
12352211
NACRES:
NA.75

生物源

Escherichia coli (O26:B6)

品質等級

無菌

γ-irradiated

產品線

BioXtra

形狀

lyophilized powder

純化經由

gel-filtration chromatography

技術

cell culture | mammalian: suitable

雜質

<5% Protein (Lowry)

溶解度

H2O: 5 mg/mL, slightly hazy

儲存溫度

2-8°C

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應用

来自 大肠杆菌026:B6的脂多糖用于引发人PBMC、小鼠骨髓树突细胞 和大鼠星形胶质细胞分泌细胞因子。
脂多糖(LPS)是革兰氏阴性细菌细胞壁的特征成分。LPS及其脂质A部分通过Toll样受体4(TLR4)刺激先天免疫系统的细胞,TLR4是Toll样受体蛋白家族的成员,该家族可识别常见的病原体相关分子模式(PAMP)。

生化/生理作用

LPS是大多数革兰氏阴性细菌细胞壁的主要成分。它是一种高免疫原性抗原,可增强对可溶性抗原的免疫应答。LPS也是小鼠、兔、鸡、牛、仓鼠和人的骨髓源B淋巴细胞的特异性促分裂原。

重構

脂多糖以冻干的γ--辐射粉末形式提供。复溶时,向样品瓶(1 mg)中加1 ml无菌平衡盐溶液或组织培养基,轻轻涡旋,直至粉末溶解。可使用无菌平衡盐溶液或组织培养基将复溶产品进一步稀释至所需工作浓度。

其他說明

为了全面了解我们针对客户研究提供的各种脂多糖产品,建议您访问我们的碳水化合物分类页面。

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 2 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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The cellular prion protein (PrP In order to explore putative roles for PrP All LPS-treated goats displayed clinical signs of sickness behavior, which were of significantly (p < 0.01) longer duration in animals without PrP Our data suggest that PrP
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Emerging evidence suggests that maternal or developmental vitamin D (DVD) deficiency is a risk factor for Autism Spectrum Disorders. A well-established association has also been found between gestational infection and increased incidence of autism. Placenta mediates the maternal immune response
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