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生物源
human
品質等級
重組細胞
expressed in E. coli
化驗
≥95% (HPLC)
形狀
lyophilized powder
效力
0.1-10 ng/mL ED50/EC50
品質
endotoxin tested
分子量
~7.6 kDa
包裝
pkg of 50 and 100 μg
技術
cell culture | mammalian: suitable
雜質
≤1.00 EU/μg
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... IGF1(3479) , Igf1(16000)
一般說明
Insulin-like growth factor I (IGF-I) is localized on human chromosome 12q23.2.
應用
Insulin-like Growth Factor-I human has been used:
- in modified Dulbecco minimal essential medium for in vitro culture of testicular cells
- in culture media, to study its effect on steroidogenesis during testicular development
- in culture media for in vitro assay of splenic pro-erythroid cell growth and differentiation
生化／生理作用
IGF-I also known as somatomedin C, is secreted from the liver into circulation in a process regulated by pituitary growth hormone (GH) and so it mediates the growth-promoting activity of GH. In the developing embryo IGF-I is expressed primarily by mesenchymal-derived cells. After birth IGF-I expression in most extrahepatic tissues declines and hepatic expression of IGF-I becomes GH-regulated. Expression of IGF-I outside the liver is regulated differently, depending on the specific tissues. For example, gonadotropins and sex steroids regulate IGF-I expression within the reproductive system, while parathyroid hormone and sex steroids regulate IGF-I expression in bone. IGF-I is produced in several human tumors. IGF-I is mitogenic for a variety of cells including fibroblasts, osteoblasts, smooth muscle cells, fetal brain cells, neuroglial cells, and erythroid progenitor cells. IGF-I exerts its actions exclusively through the IGF-I receptor (IGF-IR). IGF-I induces endothelial cell migration and is involved in the regulation of angiogenesis.
Insulin-like growth factor I (IGF-I) plays a critical role in cellular energy metabolism and growth and development, especially prenatal growth.
外觀
Lyophilized from 0.2 μm filtered solution in 50 mM acetic acid.
重構
Reconstitute in water
分析報告
The biological activiy is calculated by the dose-dependent proliferation of murine BALBC/3T3 cells. ED50 corresponds to a specific activity of at least 1 x 105 units/mg.
相關產品
产品编号
说明
价格
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Shu-Lin Liu et al.
Molecular cell, 71(6), 1092-1104 (2018-09-04)
Activation of class I phosphatidylinositol 3-kinase (PI3K) leads to formation of phosphatidylinositol-3,4,5-trisphophate (PIP3) and phosphatidylinositol-3,4-bisphophate (PI34P2), which spatiotemporally coordinate and regulate a myriad of cellular processes. By simultaneous quantitative imaging of PIP3 and PI34P2 in live cells, we here show
Juan E Puche et al.
Journal of translational medicine, 10, 224-224 (2012-11-15)
Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes. IGF-I is partly responsible for systemic GH activities
A comparison of the effects of equine luteinizing hormone (eLH), equine growth hormone (eGH) and human recombinant insulin-like growth factor (hrIGF-I) on steroid production in cultured equine Leydig cells during sexual maturation
Hess MF and Roser JF
Animal Reproduction Science, 89(1-4), 7-19 (2005)
An optimized system for studies of EPO-dependent murine pro-erythroblast development
Zhang D, et al.
Experimental Hematology, 29(11), 1278-1288 (2001)
M J E Walenkamp et al.
Endocrine development, 24, 128-137 (2013-02-09)
Molecular defects of the insulin-like growth factor 1 gene (IGF1) are rare in the human. Only three homozygous and two families with heterozygous mutations of the IGF1 gene have been described, resulting in a variable degree of intrauterine and postnatal
商品
Insulin-like Growth Factors (IGF)
实验方案
产生人诱导多能干细胞（iPSC）的干细胞重编程实验方案，包括基于病毒和非病毒RNA的方法。
Stem cell reprogramming protocols to generate human induced pluripotent stem cells (iPSCs) including viral and non-viral RNA based methods.
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