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Merck

I1645

Sigma-Aldrich

白细胞介素8 人

≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

别名:

IL-8

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About This Item

MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.32

生物源

human

品質等級

重組細胞

expressed in E. coli

化驗

≥98% (SDS-PAGE and HPLC)

形狀

lyophilized powder

分子量

8.4 kDa

包裝

pkg of 10 μg

技術

cell culture | mammalian: suitable

雜質

endotoxin, tested

UniProt登錄號

儲存溫度

−20°C

基因資訊

human ... IL8(3576)

應用

白细胞介素-8 (IL-8) 用于:
  • 测量中性粒细胞化学毒性
  • 脑膜上皮细胞摄取凋亡细胞的研究
  • IL-8 对人脐静脉内皮细胞表达和分泌尿促皮素-1 的影响

生化/生理作用

白细胞介素-8 (IL-8) 以往称为单核细胞衍生的中性粒细胞趋化因子,属于趋化因子 αC-X-C 家族。IL-8 的成熟形式有 4 个半胱氨酸残基,趋化因子家族的其他成员也是如此,前两个半胱氨酸残基被谷氨酰胺分开。成熟人 IL-8 由 72 个氨基酸组成,分子量为 8.4 kDa。IL-8 在体外 对 T 细胞、嗜碱性粒细胞表现出趋化活性 ,通过酶包括髓过氧化物酶、α-甘露糖苷酶和 β-葡萄糖醛酸酶。IL-8 是一种血管生成因子。
白细胞介素-8 (IL-8) 原称单核细胞源性中性粒细胞趋化因子。属于趋化因子 αC-X-C 家族。与该家族的其他成员一样,IL-8 的成熟形式有 4 个半胱氨酸残基,前 2 个半胱氨酸残基被谷氨酰胺分开。IL-8 在体外 对 T 细胞、中性粒细胞和嗜碱粒细胞具有趋化活性 IL-8 基因突变可增加急性胰腺炎的发病风险。

外觀

从 0.2 μm 冻干m 过滤溶液,无添加剂。

分析報告

生物活性取决于其化学吸引人外周血中性粒细胞的能力,浓度范围为 10.0-100.0 ng/mL。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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