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方案
≥99% (HPLC)
表单
solid
颜色
white
溶解性
DMSO: soluble 28 mg/mL
H2O: soluble 4.5 mg/mL
储存温度
2-8°C
SMILES字符串
CC(C)C(=O)c1c(nn2ccccc12)C(C)C
InChI
1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3
InChI key
ZJVFLBOZORBYFE-UHFFFAOYSA-N
基因信息
human ... PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)
生化/生理作用
Phosphodiesterase IV (PDE4) inhbitor. Inhibits platelet aggregation. Anti-asthma drug.
特点和优势
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Saatviga Sudhahar et al.
Nature communications, 15(1), 5703-5703 (2024-07-09)
Explaining predictions for drug repositioning with biological knowledge graphs is a challenging problem. Graph completion methods using symbolic reasoning predict drug treatments and associated rules to generate evidence representing the therapeutic basis of the drug. Yet the vast amounts of
Jaclyn M Schwarz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(3), 961-971 (2013-01-18)
Adolescence in humans represents a unique developmental time point associated with increased risk-taking behavior and experimentation with drugs of abuse. We hypothesized that exposure to drugs of abuse during adolescence may increase the risk of addiction in adulthood. To test
Keiko Sakuma et al.
Eye & contact lens, 35(5), 251-254 (2009-08-13)
To assess the influence of topical application of ibudilast for seasonal allergic conjunctivitis in patients wearing soft contact lenses (SCLs). There were 16 SCL wearers (32 eyes) with allergic conjunctivitis due to cedar pollen, who were studied from February to
Masahiro Noguchi et al.
Biological & pharmaceutical bulletin, 32(11), 1924-1927 (2009-11-03)
Ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-alpha]pyridine) is clinically used as a cerebral vasodilator in Japan. However, the effects of ibudilast on retinal blood vessels have not been fully examined. The aim of this study, therefore, was to examine the effects of ibudilast on retinal
Aldric T Hama et al.
Journal of neurotrauma, 29(3), 600-610 (2011-08-03)
Ibudilast, an asthma drug, has demonstrated antinociceptive effects in several rat models of peripheral neuropathic pain, and a proposed mechanism of action is the inhibition of release of the cytokine tumor necrosis factor-α (TNF-α) from activated spinal microglia. Spinal glial
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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