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598226

Sigma-Aldrich

Thiostrepton

≥98% (HPLC), powder, FOXM1 inhibitor, Calbiochem®

别名:

硫链丝菌素, FOXM1抑制剂I

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About This Item

经验公式（希尔记法）:
C72H85N19O18S5
CAS号:
1393-48-2
分子量:
1664.89
MDL號碼:
MFCD00135828
分類程式碼代碼:
12352200
NACRES:
NA.77

product name

硫链丝菌素, Thiostrepton, CAS 1393-48-2, is an antibiotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit.

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
desiccated
protect from light

顏色

off-white

溶解度

DMSO: 10 mg/mL
chloroform: 10 mg/mL

運輸包裝

ambient

儲存溫度

2-8°C

InChI

1S/C72H85N19O18S5/c1-14-26(3)47-63(105)78-30(7)57(99)75-28(5)56(98)76-31(8)58(100)91-72-19-18-40(66-85-43(22-111-66)59(101)77-29(6)55(97)74-27(4)54(73)96)81-52(72)42-21-112-67(83-42)49(34(11)109-69(107)41-20-37(32(9)92)36-16-17-39(79-47)51(95)50(36)80-41)89-60(102)44-24-113-68(86-44)53(71(13,108)35(12)94)90-62(104)45-23-110-65(84-45)38(15-2)82-64(106)48(33(10)93)88-61(103)46-25-114-70(72)87-46/h15-17,20-22,24-26,30-35,39,45,47-49,51-53,79,92-95,108H,4-6,14,18-19,23H2,1-3,7-13H3,(H2,73,96)(H,74,97)(H,75,99)(H,76,98)(H,77,101)(H,78,105)(H,82,106)(H,88,103)(H,89,102)(H,90,104)(H,91,100)/b38-15+

InChI 密鑰

NSFFHOGKXHRQEW-DVRIZHICSA-N

一般說明

一种从链霉菌属远青链霉菌中分离出来的含噻唑多肽抗生素。通过与50S亚基GTPase中心的23S rRNA非共价，但几乎不可逆地结合，抑制细菌蛋白质合成和核糖体GTPase活性。硫链丝菌素结合直接阻止与延伸因子G（EF-G）核糖体的结合，延伸因子G也与23S rRNA特异性结合。硫链丝菌素已被证明在阐明翻译的分子机制，特别是核糖体易位的分子机制方面很有用。它还用于在链霉菌属细菌中选择含有tsr基因（蓝色链霉菌）的载体，该基因编码23S rRNA甲基化酶，其作用阻止硫链丝菌素与核糖体结合。
一种含噻唑的肽抗生素，通过阻止GTP与50S核糖体亚单位的结合来抑制蛋白质合成。抑制延伸因子G（EF-G）的功能和EF-G与核糖体的分离。抗硫链菌素基因也常用作重组DNA/质粒技术的选择标记。

生化／生理作用

主要靶标
EF-G

警告

毒性：标准处理（A）

其他說明

Rodnina, M.V., et al. 1999.Proc.Natl.Acad.Sci USA96, 9586.
Rosendahl, G. and Douthwaite, S. 1994.Nucleic Acids Res.22, 357.
Saarma, U. and Remme, J. 1992.Nucleic Acids Res.20, 3147.
Malina, H. and Robert-Gero, M. 1992.Appl. Environ.Microbiol.58, 895.
Blanco, G., et al. 1992.Gene112, 59.
Miller, S.P. and Bodley, J.W.1991.Nucleic Acids Res.19, 1657.
Ryan, P.C., et al. 1991.J. Mol.Biol.221, 1257.
Kutay, U.R., et al. 1990.Biochim.Biophys.Acta1050, 193.
Smokvina, T., et al. 1990.Gene94, 53.
Garrett, R. 1983.Trends Biochem.Sci.8, 189.
Bodley, J.W., et al. 1970.Biochem.Biophys.Res. Commun.41, 1406.
Thompson, J. and Cundliffe, E. 1970.Biochimie 73, 1131.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Genetic studies implicate the oncogenic transcription factor Forkhead Box M1 (FOXM1) as a potential therapeutic target in high-grade serous ovarian cancer (HGSOC). We evaluated the activity of different FOXM1 inhibitors in HGSOC cell models. We treated HGSOC and fallopian tube
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