推荐产品
product name
HMG-1 人, lyophilized powder, ≥90% (SDS-PAGE), Histidine-tagged, recombinant, expressed in E. coli
重組細胞
expressed in E. coli
品質等級
化驗
≥90% (SDS-PAGE)
形狀
lyophilized powder
分子量
25 kDa
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
COC(=O)CCCCCCCCCCCCCCO
基因資訊
human ... HMGB1(3146)
一般說明
HMG-1（高迁移率族蛋白）是分子量为30kDa的核蛋白。它由巨噬细胞、单核细胞和坏死细胞分泌。它广泛表达。该蛋白质具有碱性 HMG（高迁移率族）盒结构域和酸性羧基末端。
215 amino acids; comprises two homologous HMG boxes, rich in basic amino acids, and an acidic tail at the carboxy-terminus
應用
HMG-1（高迁移率族蛋白）人已用于：
- 使用ELISA（酶联免疫吸附测定）测试，制备用于测量 HMG1的标准曲线
- 研究在外源 HMG-1 存在下 Lewis细胞的凋亡比例
- 研究在体外条件下，HMG-1 存在时，Th（T辅助细胞）-17细胞扩增的变化
- 用于GM7373细胞的迁移测定
生化／生理作用
HMG-1（高迁移率族蛋白）是非组蛋白染色体蛋白，其促进蛋白质序列特异性 DNA 附着。HMG1以非序列特异性方式结合 DNA。它参与DNA 复制、转录和修复。此外，它在癌症中上调并且与细胞生长、血管发生和细胞凋亡调节有关。在感染或损伤的情况下，HMG1 被分泌并介导炎症。它与自身免疫疾疾病的发病机制有关，例如类风湿性关节炎（RA）、炎性肠病（IBD）和系统性红斑狼疮（SLE）。
外觀
含有HEPES 缓冲盐，pH 7.8，NaCl，EDTA，Triton X-100，亮抑酶肽和AEBSF的冻干粉。
分析報告
DNA 延迟测定试验
訊號詞
Danger
危險聲明
危險分類
Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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