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Merck

H2508

Sigma-Aldrich

马尿酸-Arg

carboxypeptidase substrate, chromogenic, ≥98% (TLC), powder

别名:

N-苯甲酰-Gly-Arg

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About This Item

经验公式(希尔记法):
C15H21N5O4
CAS号:
分子量:
335.36
EC號碼:
MDL號碼:
分類程式碼代碼:
12352204
PubChem物質ID:
NACRES:
NA.32

product name

马尿酸-Arg, carboxypeptidase substrate

化驗

≥98% (TLC)

形狀

powder

溶解度

water: 50 mg/mL, clear, colorless to faintly yellow

儲存溫度

−20°C

SMILES 字串

NC(=N)NCCC[C@H](NC(=O)CNC(=O)c1ccccc1)C(O)=O

InChI

1S/C15H21N5O4/c16-15(17)18-8-4-7-11(14(23)24)20-12(21)9-19-13(22)10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,19,22)(H,20,21)(H,23,24)(H4,16,17,18)/t11-/m0/s1

InChI 密鑰

GFLCPYUSPYXNBV-NSHDSACASA-N

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應用

Hippuryl-Arg 已被用作
  • 来自谷斑皮蠹
  • 的氨基肽酶、来自油橄榄果实蝇Gmelin 的外肽酶、来自毕赤酵母
  • 的中肠的底物

生化/生理作用

Hippuryl-Arg 是羧肽酶 B 和氨肽酶的合成底物。羧肽酶作用于精氨酸和赖氨酸的 C 端。

基底

羧肽酶底物B 和羧肽酶N.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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H Schweisfurth et al.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 21(10), 605-609 (1983-10-01)
Kininase I (carboxypeptidase N; EC 3.4.17.3) consists of carboxypeptidase N1 (CN1) and carboxypeptidase N2 (CN2); these two enzymes can be differentiated by their activities towards hippuryl-L-arginine and hippuryl-L-lysine, respectively. A spectrophotometric assay for both carboxypeptidases in human serum is described
Digestion and protein metabolism of Trogoderma granarium (Coleoptera: Dermestidae) fed on different barley varieties
Mardani-Talaee M, et al.
Journal of Stored Products Research, 73, 37-41 (2017)
K Shibata et al.
Journal of bacteriology, 168(2), 1045-1047 (1986-11-01)
Mycoplasma salivarium produced citrulline, ammonia, and ATP from N-benzoylglycyl-L-arginine. The activity was inhibited by EDTA and was therefore concluded to be due to an arginine-specific carboxypeptidase. The activity was also found to exist in M. orale, M. buccale, M. faucium
Expression, purification and characterization of porcine pancreatic Carboxypeptidase B from Pichia pastoris for the conversion of recombinant human insulin
Mansur M, et al.
Enzyme and Microbial Technology, 40(3), 476-480 (2007)
Hidefumi Komura et al.
Microbiology and immunology, 46(2), 115-117 (2002-04-10)
Carboxypeptidases (CP) in plasma and sera serve as regulators of anaphylatoxins such as C3a and C5a. The activity of CP can be measured by determining hippuric acid after cleavage of the small synthetic substrate hippuryl-L-arginine. Although a colorimetric assay is

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