F7307
Fotemustine
≥98% (HPLC)
别名:
(+-)-Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate, Muphoran, Mustophorane, P-[1-[[[(2-Chloroethyl)nitrosoamino]carbonyl]amino]ethyl]-phosphonic acid diethyl ester, S 10036
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所有图片(1)
About This Item
经验公式（希尔记法）:
C9H19ClN3O5P
CAS号:
分子量:
315.69
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
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化驗
≥98% (HPLC)
形狀
powder
儲存條件
protect from light
顏色
light yellow
溶解度
H2O: ≥1 mg/mL
起源
Servier
儲存溫度
2-8°C
SMILES 字串
CCOP(=O)(OCC)C(C)NC(=O)N(CCCl)N=O
InChI
1S/C9H19ClN3O5P/c1-4-17-19(16,18-5-2)8(3)11-9(14)13(12-15)7-6-10/h8H,4-7H2,1-3H3,(H,11,14)
InChI 密鑰
YAKWPXVTIGTRJH-UHFFFAOYSA-N
生化／生理作用
Fotemustine is a third generation nitrosourea, chloroethylating agent used in the treatment of glioma and malignant melanoma.
特點和優勢
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Servier. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Xavier Durando et al.
Bulletin du cancer, 100(1), 23-28 (2012-08-15)
Brain metastases affect 37% of patients suffering from metastatic melanoma, and their prognosis remains poor, with an overall survival lower than six months. At the moment, there is no standard therapeutic strategy for management of melanoma brain metastases. In some
M Santoni et al.
Anticancer research, 32(3), 1099-1101 (2012-03-09)
Alkylating agents, such as temozolomide (TMZ) and fotemustine (FTM) are widely used in recurrent glioblastoma (GBM) regimes. Several strategies have been proposed to prevent resistance to these agents, by combining or sequencing them. We report the results of a pilot
Ipilimumab with fotemustine in metastatic melanoma.
Claus Garbe
The Lancet. Oncology, 13(9), 851-852 (2012-08-17)
Anna Maria Di Giacomo et al.
The Lancet. Oncology, 13(9), 879-886 (2012-08-17)
Ipilimumab improves survival of patients with metastatic melanoma, many of whom develop brain metastases. Chemotherapy-induced release of tumour antigens might amplify ipilimumab's antitumour activity. We aimed to investigate the efficacy and safety of ipilimumab plus fotemustine in patients with metastatic
Silvia Mangiacavalli et al.
American journal of hematology, 88(2), 102-106 (2012-12-12)
Since multiple myeloma (MM) is still not-curable, the management of relapse remains challenging. Given the known efficacy of alkylating agents in MM, we conducted a phase I/II study to test a new three drug combination in which Fotemustine (Muphoran), an
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Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
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