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Merck

F6803

Sigma-Aldrich

D-果糖1,6-双磷酸 三钠盐 水合物

≥98% (TLC)

别名:

D(+)果糖1,6-二磷酸 三钠盐 水合物, 哈杨二氏酯, 己糖二磷酸 三钠盐 水合物

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About This Item

经验公式(希尔记法):
C6H11Na3O12P2 · xH2O
CAS号:
分子量:
406.06 (anhydrous basis)
MDL號碼:
分類程式碼代碼:
12352201
PubChem物質ID:
NACRES:
NA.25

生物源

microbial

品質等級

化驗

≥98% (TLC)

形狀

powder

技術

thin layer chromatography (TLC): suitable

顏色

white to off-white

溶解度

water: 50 mg/mL, clear, colorless to faintly yellow

正離子痕跡

Na: 14.6-18.8% (dry basis)

儲存溫度

−20°C

SMILES 字串

O.[Na+].[Na+].[Na+].O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H](O)C(=O)COP(O)([O-])=O

InChI

1S/C6H14O12P2.3Na.H2O/c7-3(1-17-19(11,12)13)5(9)6(10)4(8)2-18-20(14,15)16;;;;/h3,5-7,9-10H,1-2H2,(H2,11,12,13)(H2,14,15,16);;;;1H2/q;3*+1;/p-3/t3-,5-,6-;;;;/m1..../s1

InChI 密鑰

ISLNIFDAODOXHN-GNWSQLALSA-K

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應用

D-果糖-1,6-二磷酸(FBP)是一种常见的代谢糖,它是糖酵解途径中 3-磷酸甘油醛和磷酸二羟丙酮的前体。 它可用作酶(如丙酮酸激酶和 NAD+ 依赖型 L-(+)-乳酸脱氢酶)的变构激活剂,可作为乙酸激酶的抑制剂,以及用作鉴定和表征酶(例如果糖-1,6-二磷酸醛缩酶和果糖-1,6-二磷酸酶)的底物。 研究人员研究了FBP 作为脑损伤中神经保护剂的作用。

生化/生理作用

1,6-二磷酸果糖(F1,6P) 是一种糖酵解中间体,通过磷酸果糖激酶将磷酸盐从 ATP 转移到 6-磷酸果糖而产生。 1,6-二磷酸果糖与 2,6-二磷酸果糖一起调节磷酸果糖激酶 1 (PFK-1) 的活性,这是糖酵解中的限速步骤。 在糖酵解过程中,醛缩酶将 1,6-二磷酸果糖裂解为磷酸二羟丙酮(DHAP) 和磷酸甘油醛。1,6-二磷酸果糖也是丙酮酸激酶 (PK-M2) 的 M2 异构体的变构激活剂, M2 异构体是癌细胞中丙酮酸激酶的主要形式。

其他說明

为了全面了解我们针对客户研究提供的各种单糖产品,建议您访问我们的碳水化合物分类页面。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Fructose-1,6-diphosphate (FDP) is a metabolite in the glycolytic pathway created from glucose. Exogenously administered FDP increases the yield of ATP from anaerobic glycolysis. FDP reduces ischaemic tissue area in experimentally-induced cerebral and myocardial infarction and improves haemodynamics post-cardiac bypass. We
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Reciprocal regulation of metabolism and signaling allows cells to modulate their activity in accordance with their metabolic resources. Thus, amino acids could activate signal transduction pathways that control cell metabolism. To test this hypothesis, we analyzed the effect of amino
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Molecular and cellular biochemistry, 366(1-2), 31-39 (2012-03-20)
Previously, we reported that fructose-1,6-bisphosphate (FBP) was taken up by rat cardiac myocytes by two processes: a component that was saturable at micromolar levels and a nonsaturable component that dominated at millimolar levels. Here, we continued to characterize the saturable
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