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Merck

F5006

Sigma-Aldrich

2-氟-2-脱氧-D-葡萄糖

glycosylation inhibitor, glucose analog

别名:

2-脱氧-2-氟-D–葡萄糖, FDG, 2-脱氧-2-氟-D-葡萄糖

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About This Item

经验公式(希尔记法):
C6H11FO5
CAS号:
分子量:
182.15
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.32

品質等級

儲存溫度

2-8°C

SMILES 字串

OCC1OC(O)C(F)C(O)C1O

InChI

1S/C6H11FO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1H2

InChI 密鑰

ZCXUVYAZINUVJD-UHFFFAOYSA-N

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相关类别

一般說明

2-氟-2-脱氧-D-葡萄糖无毒,是葡萄糖的结构类似物,显著抑制了糖基化。作为葡萄糖类似物,2-氟-2-脱氧-D-葡萄糖在大脑和心脏细胞中可被迅速摄取。

2-氟-2-脱氧-D-葡萄糖可以被细胞吸收,但不进行代谢性糖酵解。

應用

2-氟-2-脱氧-D-葡萄糖被用作快速肿瘤检测的示踪剂。它被用作葡萄糖模拟物,以研究辐射和烧伤小鼠的葡萄糖摄取。肿瘤治疗研究使用FDG联合PET(正电子发射地形图)

生化/生理作用

抑制细胞糖基化的葡萄糖类似物。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Dennis Vriens et al.
Cancer, 117(20), 4582-4594 (2011-03-25)
Indeterminate results at fine-needle aspiration biopsy (FNAB) of thyroid nodules pose a clinical dilemma, because only 20% to 30% of patients suffer from malignancy. Previous studies suggested that the false-negative ratio of [(18)F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) is very low; therefore
Maarten J Vosselman et al.
The American journal of clinical nutrition, 98(1), 57-64 (2013-05-31)
Studies in rodents have shown that brown adipose tissue (BAT) is activated on food intake, thereby reducing metabolic efficiency. The current study investigated whether a single high-calorie, carbohydrate-rich meal activates BAT in lean human adults. BAT activity was studied in
P Som et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 21(7), 670-675 (1980-07-01)
Rapid uptake of F-18 FDG was observed in a variety of transplanted and spontaneous tumors in animals. The tumor uptake reached a peak by 30 min and remained relatively constant up to 60 min, with a very slow wash-out of
Frank J Brooks et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(1), 37-42 (2013-11-23)
The number of studies in the literature involving quantification of the metabolic heterogeneity seen in (18)F-FDG PET images has increased sharply over recent years. We hypothesized that inclusion of very small regions of interest as unique data points will have
C J Hoekstra et al.
European journal of nuclear medicine, 27(6), 731-743 (2000-07-20)
[18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) is considered a valuable tool in the diagnosis and staging of cancer. In addition, it seems promising as a technique to monitor response to therapy. Progress is hampered, however, by the fact that various

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