所有图片(1)
About This Item
经验公式（希尔记法）:
C8H15NO3
CAS号:
分子量:
173.21
Beilstein:
4175740
MDL號碼:
分類程式碼代碼:
51102829
PubChem物質ID:
NACRES:
NA.85
推荐产品
生物源
Metarrhizium anisopliae
品質等級
化驗
≥98% (TLC)
形狀
lyophilized powder
儲存條件
(Keep container tightly closed in a dry and well-ventilated place.)
顏色
white to faint yellow
溶解度
H2O: soluble 1 mg/mL
抗生素活性譜
neoplastics
作用方式
enzyme | inhibits
儲存溫度
2-8°C
SMILES 字串
O[C@@H]1CCCN2C[C@@H](O)[C@@H](O)C12
InChI
1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7?,8-/m1/s1
InChI 密鑰
FXUAIOOAOAVCGD-DCDLSZRSSA-N
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應用
Swainsonine is an indolizidine alkaloid from the plant Metarrhizium anisopliae that is used as a potent α-mannosidase inhibitor. Product S8195 has been used in chemical inhibition assays of CHO Lec2 cells to inhibit glycosylation .
苦马豆素是各种α-甘露糖苷酶的有效抑制剂，特别是α-甘露糖苷酶II。它能够抑制糖蛋白加工，也可作为免疫调节剂。
生化／生理作用
Swainsonine is a potent α-mannosidase inhibitor. It also has antimetastatic, antiproliferative, and immunomodulatory activity . It also inhibits glycoprotein processing.
包裝
1MG
準備報告
Soluble in water, methanol, DMSO
其他說明
Keep container tightly closed in a dry and well-ventilated place.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Shen Shen et al.
The Journal of biological chemistry, 286(15), 13532-13540 (2011-02-19)
Sialylated glycans serve as cell surface attachment factors for a broad range of pathogens. We report an atypical example, where desialylation increases cell surface binding and infectivity of adeno-associated virus (AAV) serotype 9, a human parvovirus isolate. Enzymatic removal of
W J Croom et al.
Journal of animal science, 73(5), 1499-1508 (1995-05-01)
The history of "slobbers syndrome," a mycotoxicosis associated with Rhizoctonia leguminicola infestation of pastures and stored forages, is discussed. The chemistry and physiological effects of the two known biologically active alkaloids of R. leguminicola, slaframine and swainsonine, are described. Slaframine
Daniel S Grum et al.
Journal of natural products, 76(10), 1984-1988 (2013-09-24)
Legumes belonging to the Astragalus, Oxytropis, and Swainsona genera have been noted by ranchers in the Americas, Asia, and Australia to cause a neurologic disease often referred to as locoism or peastruck. The toxin in these legumes is swainsonine, an
K Olden et al.
Pharmacology & therapeutics, 50(3), 285-290 (1991-01-01)
Swainsonine, an indolizidine alkaloid, was initially used in biomedical research as a tool to investigate the biosynthesis and function of asparagine-linked 'complex' type oligosaccharide moieties of glycoproteins. Recently, swainsonine has generated interest in its potential use as an anticancer agent
The indolizidine alkaloids, slaframine and swainsonine: contaminants in animal forages.
H P Broquist
Annual review of nutrition, 5, 391-409 (1985-01-01)
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