推荐产品
生物源
human plasma
品質等級
化驗
>90% (SDS-PAGE)
形狀
lyophilized powder
分子量
70 kDa
包裝
pkg of 0.5 mg
技術
cell culture | mammalian: suitable
雜質
HIV and HBsAg, source material tested negative
Small proteolytic fragments, may contain traces
溶解度
water: soluble ≥0.500 mg/mL, clear to slightly hazy, colorless
UniProt登錄號
運輸包裝
ambient
儲存溫度
−20°C
基因資訊
human ... FN1(2335)
正在寻找类似产品? 访问 产品对比指南
一般說明
Fibronectin 1 is a glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. FN1 is mapped to human chromosome 2q35. Proteolytic fragments of fibronectin has a cell binding domain.
應用
Fibronectin Proteolytic Fragment from human plasma has been used in pre adsorbed antibody blocking assay and EC-pericyte tube coassembly.
生化／生理作用
Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, hemostasis and thrombosis. Proteolytic fragments of fibronectin plays a vital role in mononuclear phagocyte function.
注意
The product should be stored at -20°C.
準備報告
This product is lyophilized from phosphate buffered saline with sucrose as a cryoprotectant. The source material has tested negative for antibody to HIV, HCN, and HBsAg. It is soluble in water at 0.5 mg/mL and yields a clear to slightly hazy solution.
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Fibronectin in Health and Disease (2018)
C Penn et al.
Microbial pathogenesis, 17(6), 387-393 (1994-12-01)
Candida albicans yeast cells bind soluble human plasma fibronectin (Fn) through a glycoprotein receptor (adhesin) located on the cell surface. This work demonstrates that a 120 kDa proteolytic fragment of Fn encompassing the cell binding domain binds more avidly to
Ail protein binds ninth type III fibronectin repeat (9FNIII) within central 120 kDa region of fibronectin to facilitate cell binding by Yersinia pestis.
Tsang T M, et al.
The Journal of Biological Chemistry, 287(20), 16759-16767 (2012)
Mutations F352A and Y528A in human HSP90I? reduce fibronectin association and fibrillogenesis in cell-derived matrices.
Chakraborty, et al.
Cell Stress & Chaperones (2023)
Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation.
Stratman A N, et al.
Blood, 114(24), 5091-5101 (2009)
实验方案
Dilute fibronectin for cell attachment, varying per cell type. Coating protocol, products, and FAQs provided.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门