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重组
expressed in Sf9 cells
质量水平
表单
solution
比活
≥2,000 unit/μg protein
分子量
126 kDa
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... PDE5A(8654)
一般描述
研究领域：细胞信号传导PDE5存在于肾、脑、肺、心肌细胞、血管平滑肌细胞、阴茎海绵体、血小板和胃肠道组织等多种组织中。
生化/生理作用
PDE5调节血管平滑肌收缩，并参与血小板中的NO-cGMP信号传导以控制聚集。 PDE5也可能参与大脑中cGMP信号传导的调节，并可能调节压力诱导的心脏肥大和纤维化。磷酸二酯酶（PDE）是一种用于破坏磷酸二酯键的酶。磷酸二酯酶5（PDE5）是治疗勃起功能障碍和肺性高血压治疗的分子靶标。PDE5可用于寻找新的PDE5抑制剂。PDE5特异性靶向一氧化氮（NO）激活产生的环磷酸鸟苷（cGMP）。PDE5调节心血管和其他组织中的cGMP信号传导。在基因水平上，PDE5以多种异构体形式表达，并经历磷酸化作为翻译后修饰，导致其激活。PDE5由于亚硝基化而通过泛素途径降解。
物理属性
N末端带有GST标签的126 kDa全长蛋白
单位定义
一个单位为在37℃和pH 7.4下每分钟将1.0皮摩尔的3′,5′-cGMP转化为5′-GMP。
外形
以含40 mM Tris-HCl（pH 8.0）、110 mM NaCl、2.2 mM KCl、0.04%吐温®20和3 mM DTT的20%甘油溶液形式提供
法律信息
TWEEN is a registered trademark of Croda International PLC
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Wesam S Ahmed et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 134, 111128-111128 (2020-12-22)
Phosphodiesterase 5 (PDE5) is one of the most well-studied phosphodiesterases (PDEs) that specifically targets cGMP typically generated by nitric oxide (NO)-mediated activation of the soluble guanylyl cyclase. Given the crucial role of cGMP generated through the activation of this cellular
Andrew T Bender et al.
Pharmacological reviews, 58(3), 488-520 (2006-09-14)
Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate the cellular levels of the second messengers, cAMP and cGMP, by controlling their rates of degradation. There are 11 different PDE families, with each family typically having several different isoforms and splice
Felicia Akuamoa et al.
Toxicology in vitro : an international journal published in association with BIBRA, 73, 105130-105130 (2021-03-05)
Herbal supplements sold as 'all natural' on various markets in Accra (Ghana) and advertised as highly efficacious in treating erectile dysfunction (ED) were bought and analysed by a PDE-5 enzyme inhibition assay. The claimed efficacy of these products could be
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