推荐产品
生物来源
goat
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
种属反应性
human
技术
indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL
UniProt登记号
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... EFNA4(1945)
一般描述
By ELISA, the antibody shows approximately 50% cross-reactivity with recombinant human ephrin-A5 and no cross-reactivity with recombinant mouse ephrin-A1, mouse ephrin-A2, human ephrin-A3, mouse ephrin-B1, mouse ephrin-B2, and mouse ephrin B3.
免疫原
recombinant human ephrin-A4, extracellular domain, expressed in NSO cells.
生化/生理作用
Ephrin A4 binds to EPH receptor A4, a protein-tyrosine kinase family that belongs to the ephrin receptor subfamily. The ephrin-A and ephrin-B ligands and regulate developmental events, particularly those of the nervous system. EphrinA4 regulates the axonal growth, astrocyte reactivity and neuroinflammation in experimental autoimmune encephalomyelitis. High expression of EphA4 receptor correlates with tumor progression, invasion and metastasis of gastric cancer and is a suitable prognostic marker.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
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储存分类代码
10 - Combustible liquids
Kathryn M Munro et al.
PloS one, 8(2), e55948-e55948 (2013-02-08)
The EphA4 receptor tyrosine kinase is a major regulator of axonal growth and astrocyte reactivity and is a possible inflammatory mediator. Given that multiple sclerosis (MS) is primarily an inflammatory demyelinating disease and in mouse models of MS, such as
Kohji Miyazaki et al.
BMC clinical pathology, 13(1), 19-19 (2013-06-07)
Erythropoietin-producing hepatocellular (Eph) receptor, consisting of a family of receptor tyrosine kinases, plays critical roles in tumour development and is considered an attractive target for cancer therapy. Tumour samples were obtained from 222 patients with gastric adenocarcinoma who underwent gastrectomy.
Manish Tandon et al.
Expert opinion on therapeutic targets, 15(1), 31-51 (2010-12-15)
High mortality rates with cancers warrant further development of earlier diagnostics and better treatment strategies. Membrane-bound erythropoietin-producing hepatocellular receptor tyrosine kinase class A2 (EphA2) is overexpressed in breast, prostate, urinary bladder, skin, lung, ovary and brain cancers. EphA2 overexpression in
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