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About This Item
经验公式（希尔记法）:
C6H10N2O2
CAS号:
分子量:
142.16
Beilstein:
7288977
EC號碼:
MDL號碼:
分類程式碼代碼:
12352204
PubChem物質ID:
NACRES:
NA.25
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一般說明
依克多因（Ectoine）是一种天然的环状四氢嘧啶，它是一种可以与水结合的低分子量有机渗透剂。它是一类小分子伴侣（small molecule chaperone，SMC）的一部分。
生化／生理作用
依克多因是多种微生物中的渗透保护剂，包括异养、嗜盐菌和非嗜盐菌，如链霉菌和大肠杆菌。这种相容性溶质对大肠杆菌在干燥和储存过程中也有保护作用。依克多因与蛋白质和脂质双层的稳定有关。它还调节膨压的保持并减轻干燥胁迫。它可以用于治疗炎症性疾病，例如过敏性鼻炎、特应性皮炎和慢性阻塞性肺疾病。依克多因可以在体外引起DNA结构变化，并保护DNA免受电离辐射（IR）的伤害。它可以防止胰岛素淀粉样蛋白在体外形成。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Ectoine and hydroxyectoine inhibit aggregation and neurotoxicity of Alzheimer?s beta-amyloid
Kanapathipillai M, et al.
Febs Letters, 579(21), 4775-4780 (2005)
G Malin et al.
Journal of bacteriology, 178(2), 385-395 (1996-01-01)
The metabolic responses of a number of Streptomyces strains to osmotic and heat stress were studied by 13C nuclear magnetic resonance spectroscopy. During cell growth in a chemically defined medium supplemented with 0.5 M NaCl, tetrahydropyrimidine derivatives (THPs), 2-methyl-4-carboxy-5-hydroxy-3,4,5,6-tetrahydropyrimidine [THP(A)]
Biosynthesis of the stress-protectant and chemical chaperon ectoine: biochemistry of the transaminase EctB
Bremer E, et al.
Frontiers in Microbiology, 10, 2811-2811 (2019)
Ectoine-containing cream in the treatment of mild to moderate atopic dermatitis: a randomised, comparator-controlled, intra-individual double-blind, multi-center trial
Marini A, et al.
Skin Pharmacology and Physiology, 27(2), 57-65 (2014)
Denise Freimark et al.
Cryobiology, 63(2), 67-75 (2011-05-31)
Human mesenchymal stem cells (hMSCs) have great potential for clinical therapy and regenerative medicine. One major challenge concerning their application is the development of an efficient cryopreservation protocol since current methods result in a poor viability and high differentiation rates.
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