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About This Item
经验公式（希尔记法）:
C24H40ClN5O8
CAS号:
分子量:
562.06
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:
NACRES:
NA.56
推荐产品
生物源
bovine
品質等級
化驗
99.5%±0.2%
形狀
lyophilized powder
純化經由
chromatography (and purified by solvent extraction)
儲存溫度
2-8°C
SMILES 字串
[Cl-].NC(CCCC[n+]1cc(CCC(N)C(O)=O)c(CCCC(N)C(O)=O)c(CCC(N)C(O)=O)c1)C(O)=O
InChI
1S/C24H39N5O8.ClH/c25-17(21(30)31)5-1-2-11-29-12-14(7-9-19(27)23(34)35)16(4-3-6-18(26)22(32)33)15(13-29)8-10-20(28)24(36)37;/h12-13,17-20H,1-11,25-28H2,(H3-,30,31,32,33,34,35,36,37);1H
InChI 密鑰
FUPMLZCXPJSGPV-UHFFFAOYSA-N
一般說明
Each vial contains 1 μmole of purified desmosine.
應用
Desmosine chloride is often used in assays for free or urinary desmosine as markers for disease states characterized by elastin degradation (e.g., emphysema). Elastin degradation has shown strong correlation with vascular calcification, and pretreatment with aluminum ions can inhibit the binding of matrix metalloproteinase (MMP) to elastin.
Assays for free or urinary desmosine are often used as markers for disease states characterized by elastin degradation (e.g., emphysema). Conversely, excessive levels of incorporated desmosine are indicators of fibrotic conditions (e.g., cirrhosis).
生化／生理作用
Desmosine is a polyfunctional amino acid that forms cross-links in mature elastin.
注意
极易吸湿
分析報告
Calibrated by UV and amino acid analysis.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Franca Cocci et al.
The international journal of biochemistry & cell biology, 34(6), 594-604 (2002-04-12)
An enhanced proteolysis of lung interstitium is key event in the pathogenesis of emphysema, a major constituent of chronic obstructive pulmonary disease. To assess whether urinary desmosine and/or hydroxyproline may be used as a marker of lung destruction we studied
M Bailey et al.
The American journal of pathology, 159(6), 1981-1986 (2001-12-26)
Calcification of elastin occurs in many pathological cardiovascular diseases including atherosclerosis. We have previously shown that purified elastin when subdermally implanted in rats undergoes severe calcification and aluminum chloride (AlCl(3)) pretreatment of elastin inhibits calcification. In the present study we
Dina M Basalyga et al.
Circulation, 110(22), 3480-3487 (2004-11-17)
Elastin calcification is a widespread feature of vascular pathology, and circumstantial evidence exists for a correlation between elastin degradation and calcification. We hypothesized that matrix metalloproteinase (MMP)-mediated vascular remodeling plays a significant role in elastin calcification. In the present studies
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