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生物源
pigeon breast
形狀
ammonium sulfate suspension
比活性
≥50 units/mg protein
濃度
≥0.4 mg/mL
技術
cell based assay: suitable
Protein ID登錄號
UniProt登錄號
儲存溫度
2-8°C
基因資訊
pigeon ... CRAT(102084317)
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一般說明
研究领域：细胞信号传导
應用
来自鸽子胸肌的乙酰肉碱转移酶已被用于酶测定。
生化／生理作用
乙酰肉碱转移酶（CrAT）是一种酶，有助于乙酰辅酶A和肉碱向乙酰肉碱和游离辅酶A的可逆转化。这种酶过程促进脂肪酸的β-氧化，从而在真核细胞的能量代谢中起关键作用。CrAT介导的乙酰肉碱生成和外流有助于维持线粒体中乙酰辅酶A和乙酰肉碱之间的平衡，再生游离辅酶A，并缓解丙酮酸脱氢酶（(PDH）生成的抑制。丙酮酸脱氢酶是葡萄糖氧化中的关键酶。该过程促进葡萄糖稳态，并有助于维持最佳的细胞能量代谢。乙酰肉碱转移酶活性也有助于细胞周期由G1向S期的转变。乙酰肉碱转移酶的缺乏也导致各种神经疾病的产生，包括阿尔茨海默病、共济失调性脑病和各种血管疾病。
肉碱乙酰转移酶通过催化乙酰辅酶A和乙酰-L-肉碱之间的平衡，维持细胞和线粒体水平的乙酰辅酶A，是氧化代谢所需的关键辅酶。 肉碱乙酰转移酶还维持着神经和非神经乙酰胆碱生产所需的乙酰辅酶A库。
單位定義
在pH 8.0，温度为25 °C的条件下，一单位酶每分钟可将1.0 μmole的乙酰-L-左旋肉碱和辅酶A转化为 L-左旋肉碱和乙酰辅酶A。
外觀
3.2M硫酸铵(NH4)2SO4晶体悬浮溶液，50mm磷酸钾，1mM二硫苏糖醇，pH 7.0
分析報告
双缩脲法测定蛋白质。
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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商品
Instructions for working with enzymes supplied as ammonium sulfate suspensions
以硫酸铵悬浮液形式提供的酶的使用指南
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