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Merck
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文件

C127

Sigma-Aldrich

CNQX

≥98% (HPLC), solid

别名:

6-氰基-7-硝基喹喔啉-2,3-二酮, FG-9065

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About This Item

经验公式（希尔记法）:
C9H4N4O4
CAS号:
115066-14-3
分子量:
232.15
MDL號碼:
MFCD00069232
分類程式碼代碼:
12352200
PubChem物質ID:
24892392
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

solid

儲存條件

protect from light

顏色

yellow

溶解度

DMSO: >10 mg/mL
H2O: insoluble

SMILES 字串

[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1C#N

InChI

1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)

InChI 密鑰

RPXVIAFEQBNEAX-UHFFFAOYSA-N

基因資訊

rat ... Gria1(50592) , Grik1(29559) , Grik2(54257) , Grik4(24406) , Grin2a(24409)

應用

CNQX已用于：
  • 作为α-氨基-3-羟基-5-甲基-4-异噁唑丙酸(AMPA)/红藻氨酸阻断剂，研究其对胚胎多能干细胞(pESC)丝状伪足(cytoneme)形成的影响
  • 作为谷氨酸阻断剂，降低触角叶中心神经元电流钳记录中的突触输入
  • 作为非N-甲基-D-天冬氨酸(NMDA)受体阻断剂，研究其对大鼠心率的影响作用

生化／生理作用

有效的竞争性AMPA/红藻氨酸谷氨酸受体拮抗剂。

其他說明

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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Frontiers in cellular neuroscience, 11, 324-324 (2017-11-11)
Release of the major excitatory neurotransmitter glutamate by synaptic vesicle exocytosis depends on glutamate loading into synaptic vesicles by vesicular glutamate transporters (VGLUTs). The two principal isoforms, VGLUT1 and 2, exhibit a complementary pattern of expression in adult brain that
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American journal of physiology. Regulatory, integrative and comparative physiology, 296(2), R299-R308 (2008-11-21)
Chronic intermittent hypoxia (CIH), as occurs in sleep apnea, impairs baroreflex-mediated reductions in heart rate (HR) and enhances HR responses to electrical stimulation of vagal efferent. We tested the hypotheses that HR responses to activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and
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Long-term depression (LTD) of synaptic efficacy is widely regarded as a cellular basis of learning and memory. The magnitude of hippocampal CA1 LTD induced by low-frequency stimulation (LFS) declines with age, but the mechanisms involved remain poorly understood. Perineuronal nets
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Paracetamol (acetaminophen, APAP) is one of the most frequently used analgesic agents worldwide. It is generally preferred over nonsteroidal anti-inflammatory drugs because it does not cause typical adverse effects resulting from the inhibition of cyclooxygenases, such as gastric ulcers. Nevertheless
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Nature communications, 8(1), 557-557 (2017-09-17)
Oligodendrocyte (OL) maturation and axon-glial communication are required for proper myelination in the developing brain. However, physiological properties of OLs remain largely uncharacterized in different brain regions. The roles of oligodendroglial voltage-activated Na+ channels (Nav) and electrical excitability in relation
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