所有图片(5)
About This Item
经验公式（希尔记法）:
C4H10NO5P
CAS号:
分子量:
183.10
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.32
推荐产品
形狀
solid
顏色
white
SMILES 字串
NC(CCP(O)(O)=O)C(O)=O
InChI
1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)
InChI 密鑰
DDOQBQRIEWHWBT-UHFFFAOYSA-N
基因資訊
human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRINA(2907)
rat ... Grin2b(24410)
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一般說明
(+)-2-氨基-4-膦酰基丁酸或 DL-AP4 是 III 组非选择性代谢型谷氨酸受体（mGluR）激动剂。L-2-氨基-4-膦酰基丁酸 (L-Ap4) 对 III 组 mGluR 的选择性接近 500 倍。
應用
(+)-2-氨基-4-膦酰基丁酸在眼组织视网膜电图研究中可用作灌注溶液中的谷氨酸受体阻滞剂。
生化／生理作用
NMDA 谷氨酸受体拮抗剂。
注意
吸湿性，干燥储存。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
H-M Zhang et al.
Neuroscience, 158(2), 875-884 (2008-11-20)
Chronic neuropathic pain remains an unmet clinical problem because it is often resistant to conventional analgesics. Metabotropic glutamate receptors (mGluRs) are involved in nociceptive processing at the spinal level, but their functions in neuropathic pain are not fully known. In
Alex S McKeown et al.
The Journal of physiology, 594(7), 1841-1854 (2015-12-23)
We propose that the end product of chromophore bleaching in rod photoreceptors, all-trans retinol, is part of a feedback loop that increases the sensitivity of the phototransduction cascade in rods. A previously described light-induced hypersensitivity in rods, termed adaptive potentiation
A Contractor et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(15), 8969-8974 (1998-07-22)
The actions of glutamate in the central nervous system are mediated through interaction with fast activating ionotropic receptors and G protein-coupled metabotropic glutamate receptors (mGluRs). Studies of these receptors have relied on the availability of agonists and antagonists selective for
Jared D Chrispell et al.
Investigative ophthalmology & visual science, 59(12), 5116-5124 (2018-10-30)
To define the functional roles of Grk1 and Grk7 in zebrafish cones in vivo. Genome editing was used to generate grk7a and grk1b knockout zebrafish. Electroretinogram (ERG) analyses of the isolated cone mass receptor potential and the b-wave were performed
Richard Fairless et al.
Investigative ophthalmology & visual science, 61(5), 37-37 (2020-05-22)
To determine the influence of RIBEYE deletion and the resulting absence of synaptic ribbons on retinal light signaling by electroretinography. Full-field flash electroretinograms (ERGs) were recorded in RIBEYE knock-out (KO) and wild-type (WT) littermate mice under photopic and scotopic conditions
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