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化驗
≥95% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white to off-white
溶解度
DMSO: ≥10 mg/mL
儲存溫度
−20°C
SMILES 字串
Cl.Cl.CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC
InChI
1S/C26H56N10.2ClH/c1-5-9-15-21(7-3)19-33-25(29)35-23(27)31-17-13-11-12-14-18-32-24(28)36-26(30)34-20-22(8-4)16-10-6-2;;/h21-22H,5-20H2,1-4H3,(H5,27,29,31,33,35)(H5,28,30,32,34,36);2*1H
InChI 密鑰
BRJJFBHTDVWTCJ-UHFFFAOYSA-N
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應用
己联双辛胍二盐酸盐已：
- 用作一种防腐剂，研究其在唾液微生物膜中的抗菌活性
- 用作一种定位于线粒体1 (PTPMT1)特异性抑制剂的蛋白酪氨酸磷酸酶，以研究其对CD8+ T细胞剩余呼吸能力和活力的影响
- 用作PTPMT1抑制剂，研究其在人巨细胞病毒(HCMV)感染的人包皮成纤维细胞(HFF)中复制的抗病毒作用
生化／生理作用
己联双辛胍二盐酸盐是一种双胍化合物。它已经被用于头颈癌的治疗。己联双辛胍二盐酸盐对几种真菌也表现出抗菌膜和抗真菌活性。由于其抗癌活性，可引起哺乳动物细胞线粒体凋亡。己联双辛胍二盐酸盐是口腔消毒剂和隐形眼镜溶液的组分。
己联双辛胍二盐酸盐是一种有效的选择性PTPMT1（线粒体蛋白酪氨酸磷酸酶1）抑制剂。己联双辛胍能够增加离体大鼠胰岛的胰岛素分泌。
特點和優勢
《受体分类和信号转导》手册的 磷蛋白磷酸酶（酪氨酸） 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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Protein tyrosine phosphatases' catalytic mechanism involves transient phosphorylation.
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