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Merck

A3105

Sigma-Aldrich

2-Amino-N-quinolin-8-yl-benzenesulfonamide

≥98% (HPLC), solid

别名:

QBS

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About This Item

经验公式(希尔记法):
C15H13N3O2S
CAS号:
分子量:
299.35
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:

化驗

≥98% (HPLC)

形狀

solid

溶解度

DMSO: soluble 22 mg/mL
H2O: insoluble

SMILES 字串

Nc1ccccc1S(=O)(=O)Nc2cccc3cccnc23

InChI

1S/C15H13N3O2S/c16-12-7-1-2-9-14(12)21(19,20)18-13-8-3-5-11-6-4-10-17-15(11)13/h1-10,18H,16H2

InChI 密鑰

NIOOKXAMJQVDGB-UHFFFAOYSA-N

生化/生理作用

Inhibitor of cell cycle at G2 phase; apoptosis inducer.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

防範說明

危險分類

Eye Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Yun-Hee Kim et al.
Biochemical pharmacology, 69(9), 1333-1341 (2005-04-14)
We screened a library of 11,000 small molecular weight chemicals, looking for compounds that affect cell viability. We have identified 2-amino-N-quinoline-8-yl-benzenesulfonamide (QBS) as a potent cytotoxic compound that induces cell cycle arrest and apoptosis. Treatment of Jurkat T cells with
Cíntia Tiemi Misugi Kayukawa et al.
Food chemistry, 303, 125388-125388 (2019-08-28)
Saponins are known for their bioactive and surfactant properties, showing applicability to the food, cosmetic and pharmaceutical industries. This work evaluated the saponins effects on Kluyveromyces lactis β-galactosidase activity and correlated these changes to the protein structure. Enzyme kinetic was
Minji Kang et al.
ACS applied materials & interfaces, 9(3), 2686-2692 (2016-12-30)
We report on the fabrication of an organic thin-film semiconductor formed using a blend solution of soluble ambipolar small molecules and an insulating polymer binder that exhibits vertical phase separation and uniform film formation. The semiconductor thin films are produced
Mónica Y Herrera-Sotero et al.
Nutrition and cancer, 72(5), 768-777 (2019-08-27)
Background: Breast and prostate cancer are frequently diagnosed neoplasias in women and men around the world. The signaling of the androgen receptor (AR) influences the development of both tumors. Since therapies focused to block the receptor's activity have not been
Fredy Omar Beltrán-Anaya et al.
Molecular oncology, 13(4), 909-927 (2019-01-17)
Triple negative breast cancer (TNBC) represents an aggressive phenotype with poor prognosis compared with ER, PR, and HER2-positive tumors. TNBC is a heterogeneous disease, and gene expression analysis has identified seven molecular subtypes. Accumulating evidence demonstrates that long non-coding RNA

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