推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
分子量
antigen ~50 kDa
物種活性
human
包裝
vial of 2 mL lyophilized antiserum
技術
immunoelectrophoresis: suitable
indirect ELISA: 1:30,000-1:60,000
UniProt登錄號
儲存溫度
2-8°C
目標翻譯後修改
unmodified
基因資訊
human ... SERPINA1(5265)
一般說明
α-1-抗胰蛋白酶属于丝酶抑制蛋白家族，是一种活性很强的丝氨酸蛋白酶抑制剂。其关键作用是保护下呼吸道免受人白细胞弹性蛋白酶的水解破坏。AAT基因突变会降低血清中α-1-抗胰蛋白酶的浓度，从而增加患肺气肿的风险。α1-抗胰蛋白酶抗体（以1:9000稀释）可用作测定转基因表达水平的捕获抗体。它也可用于免疫电泳。兔抗α1-抗胰蛋白酶抗体可与人α1-抗胰蛋白酶发生特异性反应。
免疫原
纯化人 α-1-抗胰蛋白酶
應用
α1-抗胰蛋白酶抗体（以1∶1000稀释）可用于ELISA。它也可用于探测免疫印迹以鉴定A1AT。另外，它还可用于Ouchterlony双向扩散法。
兔抗 α1-抗胰蛋白酶抗体也可用于免疫电泳技术。
此抗体已成功使用的应用，以及相关的同行评审论文如下。
蛋白免疫分析（Western Blotting）（1篇文章）
蛋白免疫分析（Western Blotting）（1篇文章）
外觀
0.01 M 磷酸盐缓冲盐水 (pH 7.2) 冻干。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Joseph E Chambers et al.
Science advances, 8(14), eabm2094-eabm2094 (2022-04-09)
Misfolding of secretory proteins in the endoplasmic reticulum (ER) features in many human diseases. In α1-antitrypsin deficiency, the pathogenic Z variant aberrantly assembles into polymers in the hepatocyte ER, leading to cirrhosis. We show that α1-antitrypsin polymers undergo a liquid:solid
Katarina Hajdin et al.
PloS one, 5(5), e10445-e10445 (2010-05-11)
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Improvement of treatment efficacy and decreased side effects through tumor-targeted drug delivery would be desirable. By panning with a phage-displayed cyclic random peptide library we selected a peptide with
U Schmidt et al.
Cellular microbiology, 1(1), 61-67 (2001-02-24)
The acute-phase response is an immediate reaction of the host against invading microorganisms. We show here that oligodeoxynucleotides (ODNs) containing a CpG motif rapidly induce the major murine acute-phase proteins in vivo, i.e. serum amyloid A (SAA) and serum amyloid
Mingming Gao et al.
Scientific reports, 9(1), 13427-13427 (2019-09-19)
Obesity and associated metabolic comorbidities represent a growing public health problem. In this study, we demonstrate the use of a newly created fusion gene of exendin-4 and α1-antitrypsin to control obesity and obesity-associated metabolic disorders including insulin resistance, fatty liver
Joerg Schuettrumpf et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 13(1), 88-97 (2005-10-19)
Identifying factors that influence gene transfer efficacy is critical for a successful gene-based clinical study. Here we demonstrate that in vivo AAV-2-mediated gene transfer is efficiently inhibited by unfractionated heparin, but not by a heparin preparation containing mainly low-molecular-weight forms
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