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Merck

51120

Sigma-Aldrich

5′-三磷酸鸟苷 钠盐 水合物

≥90% (HPLC)

别名:

GTP-Na⁺ 水合物, 5′-GTP-Na2

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About This Item

经验公式(希尔记法):
C10H16N5O14P3 · xNa+ · yH2O
CAS号:
分子量:
523.18 (anhydrous free acid basis)
Beilstein:
4113439
EC號碼:
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

品質等級

化驗

≥90% (HPLC)

形狀

powder

光學活性

[α]20/D −24±2°, c = 1% in 0.5 M Na2HPO4

雜質

≤3 mol/mol water (NMR)

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

O.O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O14P3.2Na.2H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;2*1H2/q;2*+1;;/p-2/t3-,5-,6-,9-;;;;/m1..../s1

InChI 密鑰

HPLNHYUZFVUXFJ-ZVQJTLEUSA-L

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相关类别

一般說明

5′-三磷酸鸟苷(GTP)是一种嘌呤三核苷酸磷酸。GTP是各种G-蛋白偶联受体(GPCR)GTP酶及细胞信号转导和GTP/GDP循环相关鸟嘌呤核苷酸交换因子(GEF)的底物。如需进行RNA聚合酶转录、DNA/RNA生物合成,请访问G3776产品。

應用

鸟苷 5′-三磷酸钠盐水合物已用于:
  • 作为星形胶质细胞膜片钳内液的组成部分,监测小鼠杏仁核切片星形胶质细胞的钙活性。
  • 利用电压钳技术记录细胞系中通道电流的溶液。
  • 制备内部记录注射溶液,用于将基因传递到机械感觉毛细胞。
  • 在通过体积排除色谱法(SEC)分析齐聚反应过程中,促进G界面介导的人septin蛋白同源二聚体的形成。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Hiroaki Kajiho et al.
The Journal of biological chemistry, 286(27), 24364-24373 (2011-05-19)
The small GTPase Rab5, which cycles between GDP-bound inactive and GTP-bound active forms, plays essential roles in membrane budding and trafficking in the early endocytic pathway. Rab5 is activated by various vacuolar protein sorting 9 (VPS9) domain-containing guanine nucleotide exchange
Gyu-Sang Hong et al.
Neuron, 94(2), 271-273 (2017-04-21)
Mechanosensation is essential for various physiological processes, and it is mediated by mechanotransduction channels. Recently, we reported that TMEM150C/Tentonin 3 (TTN3) confers mechanically activated currents with slow inactivation kinetics in several cell types, including dorsal root ganglion neurons (Hong et al.
Lukas Jakob Neukomm et al.
Development (Cambridge, England), 138(10), 2003-2014 (2011-04-15)
Multicellular organisms use programmed cell death to eliminate unwanted or potentially harmful cells. Improper cell corpse removal can lead to autoimmune diseases. The development of interventional therapies that increase engulfment activity could represent an attractive approach to treat such diseases.
Wei Xiong et al.
Nature protocols, 9(10), 2438-2449 (2014-09-19)
Mechanosensation, the transduction of mechanical force into electrochemical signals, allows organisms to detect touch and sound, to register movement and gravity, and to sense changes in cell volume and shape. The hair cells of the mammalian inner ear are the
J Spychala et al.
The International journal of biochemistry, 23(10), 1155-1159 (1991-01-01)
1. Phosphocellulose column chromatography under double gradient conditions (phosphate and KCl) revealed two forms of AMP deaminase in rat heart and brain and a single form in the liver and skeletal muscle. 2. Kinetically all purified AMP deaminases were classified

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