推荐产品
生物来源
mouse
质量水平
100
500
偶联物
unconjugated
抗体形式
culture supernatant
抗体产品类型
primary antibodies
克隆
MRQ-54, monoclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
表单
buffered aqueous solution
种属反应性
human
包装
vial of 0.1 mL concentrate (379M-14)
vial of 0.5 mL concentrate (379M-15)
bottle of 1.0 mL predilute (379M-17)
vial of 1.0 mL concentrate (379M-16)
bottle of 7.0 mL predilute (379M-18)
制造商/商品名称
Cell Marque®
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
同位素/亚型
IgG2b
控制
clear cell renal cell carcinoma, gallbladder epithelium
运输
wet ice
储存温度
2-8°C
可视化
membranous
基因信息
human ... CA9(768)
一般描述
CA IX are a family of zinc containing metalloproteins that catalyze the reversible hydration of CO2. Among these, CA IX is anchored to the cell membrane and is expressed in the human gastrointestinal tract, chiefly in the stomach and gall bladder. It is interesting to note that CA IX is overexpressed in epithelial malignancies of the uterus, cervix, lung, breast, and kidney; none of the associated normal tissues express this isozyme. CA IX is said to maintain the extracellular acidic pH, thus promoting cell growth in these tumors5. Preliminary data suggest consistent immunoreactivity for anti-CA IX in clear cell renal cell carcinoma (RCC); it has sensitivity of 85% to 100% for clear cell RCC and this imparts diagnostic utility. Anti-CA IX may also play a role in distinguishing clear cell RCC from chromophobe RCC. Anti-CA IX, together with antibodies against Pax 2, Ksp-cadherin, and CD117, forms a robust panel that can be used to make this distinction. Strong diffuseto-multifocal immunostaining for anti-CA IX is observed in the large majority of urothelial carcinomas as opposed to the extremely weak and focal immunoreactivity seen in collecting duct carcinoma (CDC). Anti-CA IX can thus aid in distinguishing between urothelial carcinoma and CDC6.
质量
 IVD |  NA |  NA |  NA |
联系
Carbonic Anhydrase IX (CA IX) Positive Control Slides, Product No. 379S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
制备说明
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
其他说明
For Technical Service please contact: 800-665-7284 or email: [email protected]
法律信息
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Hikmat A Al-Ahmadie et al.
The American journal of surgical pathology, 32(3), 377-382 (2008-02-28)
Carbonic anhydrase IX (CAIX)-a protein maintaining intracellular and extracellular pH-reportedly also influences regulation of cell proliferation, oncogenesis, and tumor progression. Its expression is von Hippel-Lindau-hypoxia inducible factor pathway dependent. Immunohistochemical (IHC) studies show that CAIX is diffusely overexpressed in clear
Thambi Dorai et al.
Cancer investigation, 24(8), 754-779 (2006-12-13)
Renal cell carcinoma (RCC) has the highest rate of occurrence within the US when compared with other countries. Recent advances in the basic research and molecular diagnostics of this malignancy have revealed that RCC is not a single disease, but
S Ivanov et al.
The American journal of pathology, 158(3), 905-919 (2001-03-10)
An acidic extracellular pH is a fundamental property of the malignant phenotype. In von Hippel-Lindau (VHL)-defective tumors the cell surface transmembrane carbonic anhydrase (CA) CA9 and CA12 genes are overexpressed because of the absence of pVHL. We hypothesized that these
Mari Leppilampi et al.
World journal of gastroenterology, 9(7), 1398-1403 (2003-07-11)
To systematically study the expression of carbonic anhydrase (CA) isozymes IX and XII in gastric tumors. We analyzed a representative series of specimens from non-neoplastic gastric mucosa and from various dysplastic and neoplastic gastric lesions for the expression of CA
A J Kivelä et al.
Histochemistry and cell biology, 114(3), 197-204 (2000-11-18)
Carbonic anhydrase (CA) IX and XII are transmembrane isoenzymes which are expressed in several epithelia and overexpressed in some carcinomas. They have recently been linked to von Hippel-Lindau gene-mediated carcinogenesis in that both isoenzymes are downregulated by the product of
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