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Merck

15759

Sigma-Aldrich

Kolliphor P 188

别名:

聚(乙二醇)- 嵌段 - 聚(丙二醇)- 嵌段 - 聚(乙二醇), Lutrol F68, 泊洛沙姆188

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About This Item

CAS号:
MDL號碼:
分類程式碼代碼:
12352104
NACRES:
NA.25

形狀

solid

品質等級

分子量

~7680-9510 g/mol

成份

oxyethylene, 79.9-83.7%

雜質

≤0.25% ethylene glycol and diethylene glycol
≤0.4% total ash
≤1 ppm ethylene oxide
≤1.0% water
≤2 ppm arsenic traces
≤20 ppm heavy metals
≤5 ppm dioxan
≤5 ppm propylene oxide
50-150 ppm butylhydroxytoluene

燃燒殘留物

≤0.30%

顏色

APHA: ≤120, 50/50 in CH3OH

pH值

5.0-7.5 (100 g/L in H2O)
6.0-7.5 (25 g/L in H2O)

CMC

0.48 mM

轉變溫度

cloud point >100 °C

HLB

>24

SMILES 字串

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI 密鑰

RVGRUAULSDPKGF-UHFFFAOYSA-N

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應用


  • P 188在牙科制剂中的稳定作用:研究P188对smartCrystal牙科用橙皮苷工业浓缩液的稳定作用,发现其可提高制剂的长期稳定性,有牙科治疗意义(Romero et al., 2015)。

生化/生理作用

Poloxamer 188广泛用作增稠剂和凝胶粘合剂。

其他說明

Poloxamer 188是广泛的嵌段共聚物系列泊洛沙姆(poloxamer)的一种型号。

法律資訊

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Wei Xu et al.
Drug delivery, 19(4), 208-219 (2012-05-31)
The aim of this study was to construct novel targeting polymeric micelles. Folate-Poly (ethylenimine)-Pluronic copolymers were synthesized. A paclitaxel (PTX)-loaded mixed micelles consisting of Folate-Poly (ethylenimine)-Pluronic and Pluronic L121 copolymers have been developed. The mixed micelles showed nano-sized spherical morphology.
Céline Durand-Gasselin et al.
Langmuir : the ACS journal of surfaces and colloids, 27(20), 12329-12335 (2011-09-29)
Aggregation of thermosensitive polymer-coated gold nanoparticles was performed in aqueous solution in the presence of a triblock copolymer poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (Pluronic P123, PEO(20)-PPO(68)-PEO(20)). The gold nanoparticles, AuNPs, which are covered by thermosensitive statistical copolymers poly(EO(x)-st-PO(y)), aggregate when the
Liyan Zhao et al.
Colloids and surfaces. B, Biointerfaces, 97, 101-108 (2012-05-23)
In this study, curcumin (Cur) loaded mixed micelles (Cur-PF), composed of Pluronic P123 (P123) and Pluronic F68 (F68), was prepared using the thin-film hydration method and evaluated in vitro. The preparation process was optimized with a central composite design (CCD).
A Kiwilsza et al.
Journal of microencapsulation, 30(1), 21-27 (2012-06-09)
Mesoporous material SBA-15 of hexagonal structure was synthesised and its usefulness as a carrier for a poorly soluble drug--lacidipine (LA)--was tested. The source of silica was tetraethyl orthosilicate (TEOS) and the structure ordering agent was non-ionic surfactant Pluronic P123. SBA-15
Xijun Zhang et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 31(6), 842-845 (2011-12-17)
This study examined the effect of P85 (a pluronic block copolymer) and microbubble (MB) ultrasound contrast agents under ultrasound irradiation on gene transfection and expression. The pEGFP plasmids that can encode enhanced green fluorescent protein (pEGFP) served as a report

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