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Merck

Y0000131

丁螺环酮盐酸盐 盐酸盐

European Pharmacopoeia (EP) Reference Standard

别名:

N-[4-[4-(2-嘧啶基)-1-哌嗪基] 丁基]-8-氮杂螺[4.5]癸烷-7,9-二酮 盐酸盐

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About This Item

经验公式(希尔记法):
C21H31N5O2 · HCl
CAS号:
分子量:
421.96
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

buspirone

製造商/商標名

EDQM

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-8°C

SMILES 字串

Cl[H].O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)c4ncccn4

InChI

1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H

InChI 密鑰

RICLFGYGYQXUFH-UHFFFAOYSA-N

基因資訊

human ... HTR1A(3350)

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一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Buspirone hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

5-HT 1A 血清素受体激动剂;抗焦虑药。

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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P Skolnick et al.
Pharmacotherapy, 4(6), 308-314 (1984-11-01)
Buspirone is an azaspirodecanedione that has anxiolytic actions in man and anticonflict actions in experimental animals. In contrast to many commonly used anxiolytic agents, buspirone does not appear to have significant sedative, muscle relaxant or anticonvulsant actions. Consequently, it has
M Kolcsar et al.
Acta physiologica Hungarica, 101(4), 479-487 (2014-12-24)
The role of serotonin in depression and anxiety is still highly controversial. In this experiment the effect of two substances upon anxiety was studied in rats. Forty adult (45-55 weeks old) male Wistar rats were used to study the following
H L Goldberg
Pharmacotherapy, 4(6), 315-324 (1984-11-01)
Buspirone is the first of a new class of anxioselective agents, the azaspirodecanediones. It achieves peak serum concentrations within one hour and has a serum half-life of 2 to 5 hours. Animal studies have suggested antianxiety activity and the absence

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