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Merck
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文件

I114

Supelco

对碘可乐定 盐酸盐

analytical standard, for drug analysis

别名:

2-[(2,6-二氯-4-碘苯基)亚氨基]咪唑啉 盐酸盐

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About This Item

经验公式（希尔记法）:
C9H8Cl2IN3 · HCl
CAS号:
108294-53-7
分子量:
392.45
MDL號碼:
MFCD00069292
分類程式碼代碼:
41116107
PubChem物質ID:
329815344
NACRES:
NA.24

等級

analytical standard, for drug analysis

品質等級

100

形狀

solid

技術

HPLC: suitable
gas chromatography (GC): suitable

顏色

white to off-white

溶解度

H2O: soluble

應用

forensics and toxicology
pharmaceutical (small molecule)
veterinary

格式

neat

SMILES 字串

Cl[H].Clc1cc(I)cc(Cl)c1\N=C2/NCCN2

InChI

1S/C9H8Cl2IN3.ClH/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9;/h3-4H,1-2H2,(H2,13,14,15);1H

InChI 密鑰

ULCGXOSKNHMYAX-UHFFFAOYSA-N

基因資訊

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

相关类别

應用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

生化／生理作用

高亲和性 α2 肾上腺素受体激动剂。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302 + H312 + H332

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

分析证书(COA)

Lot/Batch Number
118H4709

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Jan Höcker et al.
The Journal of pharmacy and pharmacology, 61(7), 901-910 (2009-07-11)
alpha(2)-Adrenergic and mu-opioid receptors belong to the rhodopsin family of G-protein coupled receptors and mediate antinociceptive effects via similar signal transduction pathways. Previous studies have revealed direct functional interactions between both receptor systems including synergistic and additive effects. To evaluate
H Zhu et al.
Life sciences, 61(19), 1973-1983 (1997-01-01)
One subtype of imidazoline receptors (IR1) is similar to alpha 2-adrenoceptors (alpha 2 AR) based on their high affinity for clonidine and related imidazoline compounds. On the other hand, IR1 possess low affinity for norepinephrine (NE) and other catecholamines. Imidazoline
M A Gerhardt et al.
Molecular pharmacology, 38(2), 214-221 (1990-08-01)
The binding properties of p-[125I]iodoclonidine [( 125I]PIC) to human platelet membranes and the functional characteristics of PIC are reported. [125I]PIC bound rapidly and reversibly to platelet membranes, with a first-order association rate constant (kon) at room temperature of 8.0 +/-
J E Piletz et al.
The Journal of pharmacology and experimental therapeutics, 267(3), 1493-1502 (1993-12-01)
Human platelets are shown to possess at least two high-affinity, imidazol(in)e-preferring binding sites that are pharmacologically distinct from alpha-2 adrenoceptors. These nonadrenergic sites were radiolabeled even in the presence of a 10 microM norepinephrine mask of alpha-2 adrenoceptors. Heterogeneity at
J E Piletz et al.
The Journal of pharmacology and experimental therapeutics, 279(2), 694-702 (1996-11-01)
To identify selective compounds for nonadrenergic I1-imidazoline receptors (I1), the affinities of 22 ligands for [125I]p-iodoclonidine binding have been compared at human platelet I1-imidazoline binding sites (analyzed under norepinephrine mask of alpha-2 AR) and at human alpha-2A, alpha-2B and alpha-2C
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