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H7753

Supelco

己烷雌酚

analytical standard

别名:

4,4′-(1,2-二乙基亚乙基)二苯酚, 二羟二苯己烷, 六羟春情素

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About This Item

经验公式（希尔记法）:
C18H22O2
CAS号:
84-16-2
分子量:
270.37
Beilstein:
3209460
EC號碼:
201-518-1
MDL號碼:
MFCD00068996
分類程式碼代碼:
41116107
PubChem物質ID:
329815246
NACRES:
NA.24

等級

analytical standard

品質等級

100

化驗

≥98%

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

forensics and toxicology
pharmaceutical (small molecule)
veterinary

形式

neat

SMILES 字串

CC[C@H]([C@H](CC)c1ccc(O)cc1)c2ccc(O)cc2

InChI

1S/C18H22O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,17-20H,3-4H2,1-2H3/t17-,18+

InChI 密鑰

PBBGSZCBWVPOOL-HDICACEKSA-N

基因資訊

human ... ESR1(2099)
rat ... Esr1(24890)

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一般說明

Hexestrol is a synthetic nonsteroidal estrogen, which can be used in human medicine as well as a growth promoter in cattle.

應用

Hexestrol may be used as a reference standard for the determination of the analyte in biological samples using immunoaffinity extraction and gas chromatography-negative-ion chemical ionization mass spectrometry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

生化／生理作用

The carcinogen hexestrol is a nonsteroidal synthetic estrogen. Metabolic activation of hexestrol to its quinone, which reacts with DNA to form analogous depurinating adducts, may be a primary critical event leading to oncogenic mutations and cancer initiation.

聯結

己烯雌酚的还原类似物。

推薦產品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

象形圖

Health hazard
GHS08

訊號詞

Danger

危險聲明

H350

危險分類

Carc. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 2

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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分析证书(COA)

Lot/Batch Number
MKCM4126
MKCK7639
MKCK4408
MKCH4229
MKCC7215

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R Todd Stravitz et al.
Clinics in liver disease, 7(2), 435-451 (2003-07-26)
Drugs rarely cause steatohepatitis, but amiodarone, perhexiline, and DH, have unequivocally been found to independently induce the histologic picture of alcoholic liver disease or NASH. All three agents have similar pathogenetic mechanisms of hepatotoxicity, targeting mitochondrial ATP production and fatty
ChuanLai Xu et al.
Journal of pharmaceutical and biomedical analysis, 41(3), 1029-1036 (2006-02-25)
A competitive enzyme-linked immunosorbent assay (ELISA) was developed for the quantitative detection of the hexoestrol (HES). Polyclonal rabbit antisera, raised against protein conjugate hexoestrol-mono-carboxyl-propyl-ethyl-bovine-serum-albumin (HES-MCPE-BSA), were utilized in immobilized antibody-based and competitive immunoassays. Assay conditions, including concentrations of antisera and
C Logie et al.
Molecular endocrinology (Baltimore, Md.), 12(8), 1120-1132 (1998-08-26)
Activation of the estrogen receptor (ER) by hormone involves at least two steps. First, hormone binding initially relieves repression, a property imposed on ER in cis by its ligand-binding domain (EBD). Subsequently, the derepressed ER binds specific genomic sites and
Analysis of diethylstilbestrol, dienestrol and hexestrol in biological samples by immunoaffinity extraction and gas chromatography-negative-ion chemical ionization mass spectrometry.
Bagnati R, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 527, 267-278 (1990)
A U Ziganshin et al.
Eksperimental'naia i klinicheskaia farmakologiia, 71(6), 20-22 (2009-01-15)
The results of in vitro experiments showed that hexestrol, a synthetic analog of estrogen hormones, at high concentrations inhibited the contractile response of isolated preparations of pregnant human uterus induced by ATP. It is suggested that estrogen hormones can interact
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