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Merck

43073

Supelco

扑热息痛β-D-葡萄糖醛酸苷

analytical standard

别名:

p-Acetamidophenyl β-D-glucuronide, Acetaminophen glucuronide

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About This Item

经验公式(希尔记法):
C14H17NO8
CAS号:
分子量:
327.29
Beilstein:
46644
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

analytical standard

品質等級

化驗

≥98.5% (HPLC)

儲存期限

limited shelf life, expiry date on the label

技術

HPLC: suitable
gas chromatography (GC): suitable

雜質

≤12.0% water

應用

forensics and toxicology
pharmaceutical (small molecule)

格式

neat

儲存溫度

2-8°C

SMILES 字串

O[C@@H]1[C@@H](O)[C@H](OC2=CC=C(NC(C)=O)C=C2)O[C@H](C(O)=O)[C@H]1O

InChI

1S/C14H17NO8/c1-6(16)15-7-2-4-8(5-3-7)22-14-11(19)9(17)10(18)12(23-14)13(20)21/h2-5,9-12,14,17-19H,1H3,(H,15,16)(H,20,21)/t9-,10-,11+,12-,14+/m0/s1

InChI 密鑰

IPROLSVTVHAQLE-BYNIDDHOSA-N

相关类别

應用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析证书(COA)

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Nicole J Barshop et al.
Journal of pediatric gastroenterology and nutrition, 52(2), 198-202 (2011-01-18)
: The aim of the study was to evaluate UDP-glucuronyltransferase activity and the pharmacokinetics of a single oral dose of acetaminophen (APAP) in children with nonalcoholic fatty liver disease (NAFLD). : Twelve boys 10 to 17 years old with biopsy-proven
Sifeng Mao et al.
Lab on a chip, 12(1), 219-226 (2011-11-19)
In this work, we developed a microfluidic device for the imitation of drug metabolism in human liver and its cytotoxicity on cells. The integrated microfluidic device consists of three sections: (1) bioreactors containing poly(ethylene) glycol (PEG) hydrogel encapsulated human liver
Carolina I Ghanem et al.
Biochemical pharmacology, 77(10), 1621-1628 (2009-05-12)
Development of resistance to toxic effects of acetaminophen (APAP) was reported in rodents and humans, though the mechanism is only partially understood. We examined in rats the effect of administration with subtoxic daily doses (0.2, 0.3, and 0.6g/kg, i.p.) of
Karel Allegaert et al.
Therapeutic drug monitoring, 31(4), 411-415 (2009-06-06)
Compared with phase I isoenzymes, data on isoenzyme-specific phenotypic activity of uridine diphosphate glucuronosyltransferase (UGT) and its covariates in neonates are limited. In vivo observations on morphine, paracetamol (acetaminophen), and propofol disposition throughout childhood confirm the overall low-glucuronidation activity in
Jinchun Sun et al.
Drug metabolism letters, 3(3), 130-136 (2009-08-26)
A LC/MS-based metabolomic assay was utilized to investigate a drug's excretion kinetic profile in urine so that the drug toxicity information could be obtained. Groups of 10 male Sprague-Dawley rats per dose were orally gavaged with a single dose of

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