MABN2308
Anti-TrkA Antibody, clone MNAC13
别名:
High affinity nerve growth factor receptor;EC:2.7.10.1;Neurotrophic tyrosine kinase receptor type 1;TRK1-transforming tyrosine kinase protein;Tropomyosin-related kinase A;Tyrosine kinase receptor;Tyrosine kinase receptor A;gp140trk;p140-TrkA
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About This Item
分類程式碼代碼:
12352203
NACRES:
NA.43
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生物源
mouse
品質等級
共軛
unconjugated
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
MNAC13, monoclonal
分子量
calculated mol wt 87.5 kDa
純化經由
using protein G
物種活性
human
包裝
antibody small pack of 100 μg
技術
ELISA: suitable
neutralization: suitable
同型
IgG1κ
表位序列
Extracellular domain
Protein ID登錄號
UniProt登錄號
運輸包裝
dry ice
目標翻譯後修改
unmodified
基因資訊
human ... NTRK1(4914)
一般說明
High affinity nerve growth factor receptor (UniProt: P04629; also known as EC:2.7.10.1, Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, Trk-A, gp140trk, p140-TrkA) is encoded by the NTRK1 (also known as MTC, TRK, TRKA) gene (Gene ID: 4914) in human. Trk-A is a single-pass type I membrane protein that is synthesized with a signal peptide (aa 1-32), which is subsequently cleaved off to produce the mature protein that contains an extracellular domain (aa 33-423), a transmembrane domain (aa 424-439), and a cytoplasmic domain (aa 440-796). The extracellular domain of Trk-A is composed by five domains: a leucine-rich region, two cysteine-rich domains and two immunoglobulin (Ig)-like domains. Trk-A serves as a receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous system through regulation of proliferation, differentiation, and survival of sympathetic and nervous neurons. It serves as a high affinity receptor for NGF, which is its primary ligand. It can also bind and be activated by neurotrophin-3 (NTF3). However, NTF3 only supports axonal extension through NTRK1 but does not affect neuron survival. Upon dimeric NGF ligand-binding, it undergoes homodimerization, autophosphorylation. and activation. Clone MNAC13 recognizes Trk-A with high affinity and specificity and displays a neutralizing activity toward the NGF/TrkA interaction. (Ref.: Covaceuszach, S., et al. (2005). Proteins. 58(3); :717-727; Jing, S., et al. (1992). Neuron. 9(6); 1067-1079).
特異性
Clone MNAC13 is a mouse monoclonal antibody that detects TrkA. It targets an epitope within 17 amino acids within the first Ig-like C2 type domain from the extracellular domain.
免疫原
BALB/C 3T3-transfected cells expressing human Trk-A protein.
應用
Quality Control Testing
Evaluated by ELISA with recombinant Human TrkA.
ELISA Analysis (ELISA): Various dilutions of this antibody detected recombinant Human TrkA.
Tested applications
ELISA Analysis: A representative lot detected TrkA in ELISA applications (Covaceuszach, S., et al. (2005). Proteins. 58(3):717-27).
Neutralizing: A representative lot neutralized TrkA activity in Neutralizing applications (Covaceuszach, S., et al. (2005). Proteins. 58(3):717-27; Ugolini, G., et al. (2007). Proc Natl Acad Sci USA. 104(8):2985-90).
Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
Evaluated by ELISA with recombinant Human TrkA.
ELISA Analysis (ELISA): Various dilutions of this antibody detected recombinant Human TrkA.
Tested applications
ELISA Analysis: A representative lot detected TrkA in ELISA applications (Covaceuszach, S., et al. (2005). Proteins. 58(3):717-27).
Neutralizing: A representative lot neutralized TrkA activity in Neutralizing applications (Covaceuszach, S., et al. (2005). Proteins. 58(3):717-27; Ugolini, G., et al. (2007). Proc Natl Acad Sci USA. 104(8):2985-90).
Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
Anti-TrkA, clone MNAC13, Cat. No. MABN2308, is a mouse monoclonal antibody that detects TrkA and is tested for use in ELISA and Neutralizing.
外觀
Purified mouse monoclonal antibody IgG1 in PBS without preservatives.
儲存和穩定性
Store at -10°C to -25°C. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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