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生物源
mouse
品質等級
共軛
ALEXA FLUOR™ 488
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
81 (mAB 04), monoclonal
物種活性
rat
物種活性（以同源性預測）
human (based on 100% sequence homology), bovine (based on 100% sequence homology), chicken (based on 100% sequence homology), mouse (based on 100% sequence homology)
技術
immunocytochemistry: suitable
同型
IgM
運輸包裝
wet ice
目標翻譯後修改
unmodified
一般說明
Oligodendrocytes and astrocytes are derived from common precursor cells, glioblasts (Sommer, 1981). O-Antigens are sulfatides, which function as differentiation markers on the surface of oligodendrocytes of the central nervous system. O4 is formed postnatally (Schachner, 1981) and is a marker for cell bodies and processes of oligodendrocytes types I and II (hairy eyeball type). During oligodendrocyte differentiation, O4 occurs in pro-oligodendrocytes, but not in O-2A-progenitor cells. O4 occurs from day 3 onwards in cell cultures of embryonic mouse brain. Anti-O4 can be used in myelination, demyelination and remyelination studies and in regeneration experiments.
特異性
This antibody recognizes Oligodendrocyte marker O4. Also reacts with certain galactolipids in sperm.
免疫原
Homogenate of white matter of corpus callosum from bovine brain.
應用
Anti-O4 Antibody, clone 81, Alexa Fluor™488 Conjugate detects level of O4 & has been published & validated for use in ICC.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
品質
Evaluated by Immunocytochemistry in undifferentiated rat oligodendrocyte precursor cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected O4 in undifferentiated rat oligodendrocyte precursor cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected O4 in undifferentiated rat oligodendrocyte precursor cells.
外觀
Precipitation followed by ion exchange purification
Purified mouse monoclonal IgM conjugated to Alexa Fluor™ 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
儲存和穩定性
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
分析報告
Control
Undifferentiated rat oligodendrocyte precursor cells
Undifferentiated rat oligodendrocyte precursor cells
法律資訊
ALEXA FLUOR is a trademark of Life Technologies
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Ajantha Abey et al.
Brain pathology (Zurich, Switzerland), 31(1), 144-162 (2020-08-19)
Some aged community dogs acquire a degenerative syndrome termed Canine Cognitive Dysfunction (CCD) that resembles human dementia because of Alzheimer's Disease (AD), with comparable cognitive and behavioral deficits. Dogs also have similar neuroanatomy, share our domestic environment and develop amyloid-β
Jo Anne Stratton et al.
Cell reports, 24(10), 2561-2572 (2018-09-06)
Pro-regenerative macrophages are well known for their role in promoting tissue repair; however, their specific roles in promoting regeneration of the injured nerve are not well defined. Specifically, how macrophages interact with Schwann cells following injury during remyelination has been
商品
Derivation and characterization of functional human neural stem cell derived oligodendrocyte progenitor cells (OPCs) that efficiently myelinate primary neurons in culture.
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