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產品線
Novabiochem®
化驗
≥97.0% (acidimetric)
≥98% (TLC)
≥98.0% (HPLC)
形狀
powder
反應適用性
reaction type: Fmoc solid-phase peptide synthesis
製造商／商標名
Novabiochem®
mp
95 °C (decomposes)
應用
peptide synthesis
官能基
carboxylic acid
儲存溫度
2-30°C
InChI
1S/C22H21NO6/c1-2-11-28-21(26)19(12-20(24)25)23-22(27)29-13-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h2-10,18-19H,1,11-13H2,(H,23,27)(H,24,25)/t19-/m0/s1
InChI 密鑰
ZJMVIWUCCRKNHY-IBGZPJMESA-N
一般說明
Orthogonally-protected building block for the synthesis of head-to-tail cyclic peptides [1,2,3,4,5] by Fmoc SPPS. The α-allyl ester can be selectively removed in the presence of Fmoc- and tBu-based protecting groups by treatment with Pd(Ph3P)4/ CHCl3/AcOH/NMM [6], thereby facilitating the synthesis of branched esters, amides, lactones and lactams incorporating an aspartyl unit.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Literature references
[1] W. Bannwarth, et al. (1992) Tetrahedron Lett., 33, 4557.
[2] F. Albericio, et al. (1993) Tetrahedron Lett., 34, 1549.
[3] J. Eichler, et al. (1994) Pept. Res., 7, 300.
[4] J. Eichler, et al. in ′Peptides 1994, Proc. 23rd European Peptide Symposium′, H. Maia (Eds), ESCOM, Leiden, 1994, pp. 461.
[5] J. Eichler, et al. in ′Solid Phase Synthesis & Combinatorial Libraries, 4th International Symposium′, R. Epton (Eds), Mayflower Scientific Ltd., Birmingham, 1996, pp. 201.
[6] S. A. Kates, et al. in ′Peptides, Chemistry, Structure & Biology, Proc. 13th American Peptide Symposium′, ESCOM, Leiden, 1994, pp. 113.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Literature references
[1] W. Bannwarth, et al. (1992) Tetrahedron Lett., 33, 4557.
[2] F. Albericio, et al. (1993) Tetrahedron Lett., 34, 1549.
[3] J. Eichler, et al. (1994) Pept. Res., 7, 300.
[4] J. Eichler, et al. in ′Peptides 1994, Proc. 23rd European Peptide Symposium′, H. Maia (Eds), ESCOM, Leiden, 1994, pp. 461.
[5] J. Eichler, et al. in ′Solid Phase Synthesis & Combinatorial Libraries, 4th International Symposium′, R. Epton (Eds), Mayflower Scientific Ltd., Birmingham, 1996, pp. 201.
[6] S. A. Kates, et al. in ′Peptides, Chemistry, Structure & Biology, Proc. 13th American Peptide Symposium′, ESCOM, Leiden, 1994, pp. 113.
聯結
Replaces: 04-12-1157
分析報告
Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): conforms
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(CMA2)): ≥ 98 %
Purity (TLC(157A)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 97.0 %
Water (K. F.): ≤ 1.5 %
To see the solvent systems used for TLC of Novabiochem® products please click here.
Appearance of substance (visual): powder
Identity (IR): conforms
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(CMA2)): ≥ 98 %
Purity (TLC(157A)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 97.0 %
Water (K. F.): ≤ 1.5 %
To see the solvent systems used for TLC of Novabiochem® products please click here.
法律資訊
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
商品
Novabiochem® offers orthogonally protected amino acids for peptide synthesis, including cyclic and branched peptides.
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