681629
W-7盐酸盐
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 51 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 28 µM).
别名:
W-7盐酸盐, N-(6-氨基己基)-5-氯-1-萘磺酰胺盐酸盐
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所有图片(1)
About This Item
经验公式（希尔记法）:
C16H21ClN2O2S · xHCl
CAS号:
分子量:
340.87 (free base basis)
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77
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品質等級
化驗
≥98% (TLC)
形狀
crystalline solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
protect from light
顏色
off-white
溶解度
DMSO: 5 mg/mL
DMF: soluble
warm ethanol: soluble
運輸包裝
ambient
儲存溫度
2-8°C
InChI
1S/C16H21ClN2O2S.ClH/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18;/h5-10,19H,1-4,11-12,18H2;1H
InChI 密鑰
OMMOSRLIFSCDBL-UHFFFAOYSA-N
一般說明
一种细胞渗透性和可逆性钙调蛋白拮抗剂，可抑制肌球蛋白轻链激酶（IC50 = 51 µM）和Ca2+-钙调蛋白依赖性磷酸二酯酶（IC50 = 28 µM）。
一种细胞渗透性和可逆性钙调蛋白拮抗剂，抑制Ca2+-钙调蛋白依赖性磷酸二酯酶（C50 = 28 µM）和肌球蛋白轻链激酶（IC50 = 51 µMM）。
生化／生理作用
主靶
肌球蛋白轻链激酶
肌球蛋白轻链激酶
产物不与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：51µM，抑制肌球蛋白轻链激酶；28µM，抑制Ca2+-钙调蛋白依赖性磷酸二酯酶
警告
毒性：标准处理（A）
其他說明
Caulfield, M.P., et al. 1991.Neurosci. Lett.125, 57.
Asano, M. 1989.J. Pharmacol.Exp.Ther.251, 764.
Itoh, H., and Hidaka, H. 1984.J. Biochem.96, 1721.
Tanaka, T., et al. 1983.Pharmacol.26, 249.
Hidaka, H. 1981.Proc.Natl.Acad.Sci. USA 78, 4354.
Asano, M. 1989.J. Pharmacol.Exp.Ther.251, 764.
Itoh, H., and Hidaka, H. 1984.J. Biochem.96, 1721.
Tanaka, T., et al. 1983.Pharmacol.26, 249.
Hidaka, H. 1981.Proc.Natl.Acad.Sci. USA 78, 4354.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
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Journal of cellular physiology, 232(12), 3496-3509 (2017-01-21)
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EBioMedicine, 32, 72-83 (2018-06-12)
Although psychotropic drugs act on neurons and glial cells, how glia respond, and whether glial responses are involved in therapeutic effects are poorly understood. Here, we show that fluoxetine (FLX), an anti-depressant, mediates its anti-depressive effect by increasing the gliotransmission
Susumin Yang et al.
Cell death & disease, 14(6), 391-391 (2023-07-01)
Phagocytosis of apoptotic cells, called efferocytosis, requires calcium inside and outside of phagocytes. Due to its necessity, calcium flux is sophisticatedly modulated, and the level of intracellular calcium in phagocytes is ultimately elevated during efferocytosis. However, the role of elevated
Konstantin E Komolov et al.
Molecular cell, 81(2), 323-339 (2020-12-16)
The phosphorylation of G protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) facilitates arrestin binding and receptor desensitization. Although this process can be regulated by Ca2+-binding proteins such as calmodulin (CaM) and recoverin, the molecular mechanisms are poorly understood. Here, we
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