推荐产品
product name
丙戊酸钠盐, A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC₅₀ = 400 µM for HDAC1).
品質等級
化驗
≥98% (HPLC)
形狀
solid
效力
400 μM IC50
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
顏色
white
溶解度
water: 50 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
InChI
1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
InChI 密鑰
AEQFSUDEHCCHBT-UHFFFAOYSA-M
一般說明
一种细胞可渗透性短链脂肪酸，可抑制组蛋白脱乙酰酶活性（HDAC1的IC50 = 400 µM）。诱导分化并抑制来源于人类恶性胶质瘤的细胞系的增殖。在治疗水平（350 µM-1.04 mM），引起肌醇耗竭，抑制GSK-3α和-3β，激活ERK通路，并产生神经营养效应。已被用作抗癫痫药。也有报告刺激过氧化物酶体增殖物激活受体（PPAR）活性。在人类和啮齿动物模型中显示出强效的致畸活性。
一种细胞渗透性短链脂肪酸，可抑制组蛋白脱乙酰酶（HDAC1的IC50 = 400 µM）。诱导分化并抑制来源于人类恶性胶质瘤的细胞系的增殖。在治疗水平（0.35 mM-1.04 mM），引起肌醇耗竭，抑制GSK-3α和-3β，激活ERK通路并产生神经营养作用。已被用作抗癫痫药。也有报告刺激过氧化物酶体增殖物激活受体（PPAR）活性。在人类和啮齿动物模型中显示出强效的致畸活性。
生化／生理作用
主要靶标
HDAC1
HDAC1
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
包裝
用惰性气体包装
警告
毒性：有害 & 致癌/致畸性（E）
其他說明
Gottlicher, M., et al. 2001.EMBO J.20, 6969.
Knupfer, M.M., et al. 2001.Anticancer Res.21, 347.
Phiel, C.J., et al. 2001.J. Biol. Chem.276, 36734.
Vaden, D.L., et al. 2001.J. Biol. Chem.276, 15466.
Yuan, P.X., et al. 2001.J. Biol. Chem.276, 31674.
Chen, G., et al. 1999.J. Neurochem.72, 1327.
Knupfer, M.M., et al. 2001.Anticancer Res.21, 347.
Phiel, C.J., et al. 2001.J. Biol. Chem.276, 36734.
Vaden, D.L., et al. 2001.J. Biol. Chem.276, 15466.
Yuan, P.X., et al. 2001.J. Biol. Chem.276, 31674.
Chen, G., et al. 1999.J. Neurochem.72, 1327.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Repr. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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