572635

SU6656

A potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor.

• 别名: SU6656
• 经验公式（希尔记法）: C₁₉H₂₁N₃O₃S
• CAS号: 330161-87-0
• 分子量: 371.45
• MDL编号: MFCD10565928
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥97% (HPLC)
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: burnt orange
• 溶解性: DMSO: 25 mg/mL
• 运输: ambient
• 储存温度: −20°C
• SMILES字符串: [S](=O)(=O)(N(C)C)c1cc2c(cc1)NC(=O)\C\2=C\c3[nH]c4c(c3)CCCC4
• InChI: 1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10+
• InChI key: LOGJQOUIVKBFGH-MHWRWJLKSA-N

说明

一般描述

A potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor. Inhibits Src (IC₅₀ = 280 nM) as well as closely related kinases such as Fyn (IC₅₀ = 170 nM) and Yes (IC₅₀ = 20 nM) and Lyn (IC₅₀ = 130 nM). Acts as a weak inhibitor of Lck (IC₅₀ = 688 µM) and PDGF receptor kinase (IC₅₀ >10 µM). A 10 mM (500 µg/135 µl) solution of SU6656 (Cat. No. 572636) in DMSO is also available.

生化/生理作用

Cell permeable: yes

Product competes with ATP.

Reversible: yes

Target IC₅₀: 280 nM, 170 nM, 20 nM, and 130 nM against Src, Fyn, Yes, and Lyn.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他说明

Bowman, T., et al. 2001. Proc. Natl. Acad. Sci. USA98, 7319.
Blake, R.A., et al. 2000. Mol. Cell. Biol.20, 9018.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable