567732

Sphingosine Kinase 1 Inhibitor, SKI-178

• 别名: Sphingosine Kinase 1 Inhibitor, SKI-178, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide, Nʹ-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide
• 经验公式（希尔记法）: C₂₁H₂₂N₄O₄
• 分子量: 394.42
• UNSPSC代码: 12352200
• NACRES: NA.28

属性

• 方案: ≥92% (HPLC)
• 质量水平: 100
• 表单: powder
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: off-white
• 溶解性: DMSO: 100 mg/mL
• 运输: ambient
• 储存温度: 2-8°C

说明

一般描述

A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (K_i = 1.33 and >>25 µM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC₅₀ in the range of 0.1-1.8 µM).

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他说明

Hengst, J.A., et al. 2010. .Bioorg. Med. Chem. Lett.20, 7498

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable