554994

RHC-80267

Selective inhibitor of DAG lipase activity in canine platelets (IC₅₀ = 4 nM) and in a variety of mammalian cells.

• 别名: RHC-80267, 1,6- bis(Cyclohexyloximinocarbonylamino)hexane
• 经验公式（希尔记法）: C₂₀H₃₄N₄O₄
• CAS号: 83654-05-1
• 分子量: 394.51
• MDL编号: MFCD00210844
• UNSPSC代码: 51111800
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥98% (HPLC)
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze
• 颜色: white to off-white
• 溶解性: DMSO: 25 mg/mL; ethanol: 25 mg/mL
• 运输: ambient
• 储存温度: 10-30°C
• InChI: 1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26)
• InChI key: RXSVYGIGWRDVQC-UHFFFAOYSA-N

说明

一般描述

Selective inhibitor of DAG lipase activity in canine platelets (IC₅₀ = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α.

生化/生理作用

Cell permeable: no

Primary Target
DAG lipase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 4 nM against DAG lipase activity in canine platelets

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Shinoda, J., et al. 1997. Arterioscler. Thromb. Vasc. Biol. 17, 295.
Shinoda, J., et al. 1997. Eur. J. Endocrinol. 136, 207.
Konrad, R.J., et al. 1994. Biochemistry 33, 13284.
Mason-Garcia, M., et al. 1992. Am. J. Physiol.262, C1197.
Balsinde, J., et al. 1991. J. Biol. Chem.266, 15638.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable