539749

PTP1B Inhibitor

InSolution, ≥97%

• 别名: InSolution PTP1B Inhibitor, PTP Inhibitor XXII
• 经验公式（希尔记法）: C₂₆H₁₉Br₂N₃O₇S₃
• 分子量: 741.45
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥97% (HPLC)
• 形狀: liquid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 運輸包裝: ambient
• 儲存溫度: −20°C

说明

一般說明

A cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC₅₀ = 4 µM and 8 µM for PTP1B₄₀₃ and PTP1B₂₉₈, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop.

生化／生理作用

Cell permeable: yes

IC50 = 4 and 8 µM for PTP1B403 and PTP1B298, respectively

Reversible: yes

包裝

Packaged under inert gas

警告

Toxicity: Irritant (B)

外觀

A 10 mM (2 mg/270 µl) solution of PTP1B Inhibitor (Cat. No. 539741) in DMSO.

重構

Following initial thaw, aliquot and freeze (-20°C).

其他說明

Wiesmann, C., et al. 2004. Nat. Struct. Mol. Biol.11, 730.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: 188.6 °F - closed cup - (Dimethylsulfoxide)
• 閃點（°C）: 87 °C - closed cup - (Dimethylsulfoxide)