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Merck
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文件

444151

Sigma-Aldrich

Nutlin-3

InSolution, ≥98%, Racemic, potent and selective MDM2 antagonist

别名:

InSolution Nutlin-3, Racemic, MDM2 Inhibitor IV

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About This Item

经验公式（希尔记法）:
C30H30Cl2N4O4
分子量:
581.49
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

liquid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
desiccated (hygroscopic)
protect from light

運輸包裝

wet ice

儲存溫度

−20°C

一般說明

A cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.

包裝

Packaged under inert gas

警告

Toxicity: Irritant (B)

外觀

A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143) in DMSO

重構

Following initial thaw, aliquot and freeze (-20°C).

其他說明

Thompson, T., et al. 2004. J. Biol. Chem.279, 53015.
Vassilev, L.T., et al. 2004. Science303, 844.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

188.6 °F - closed cup - (Dimethylsulfoxide)

閃點（°C）

87 °C - closed cup - (Dimethylsulfoxide)

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