5.38096

GluN2B NMDA Receptor Antagonist, 93-31

• 别名: GluN2B NMDA Receptor Antagonist, 93-31, (S)-N-(4-(3-(butyl(3,4-dichlorophenethyl)amino)-2-hydroxypropoxy)phenyl)methanesulfonamide
• 经验公式（希尔记法）: C₂₂H₃₀Cl₂N₂O₄S
• CAS号: 457897-98-2
• 分子量: 489.46
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 品質等級: 100
• 形狀: solid (sticky)
• 效力: 0.19 μM IC₅₀
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: light yellow to yellow
• 溶解度: DMSO: 100 mg/mL
• 儲存溫度: −20°C

说明

一般說明

A tertiary N-alkylamine that acts as a pH dependent antagonist of GluN2B-NMDA receptors. Shown to be about 10-fold more potent in ischemic tissue (pH 6.9) than in normal healthy tissue (pH 7.6) (IC₅₀ = 190 nM and 1.8 µM, respectively). Effectively reduces the infarct volume in damaged brain tissue in a murine model of ischemic stroke (at 10 mg/kg, ED₅₀ ≤ 1 mg/kg) without impairing coordination or motor function. Also displays binding to hERG (IC₅₀ = 70 nM) and alpha1-adrenergic receptor (IC₅₀ = 4.9 µM).

生化／生理作用

Primary Target
GluN2B NMDA Receptor

Reversible: yes

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Yuan, H., et al. 2015. Neuron.85, 1305.
Tahirovic, Y., et al. 2008. J. Med. Chem.51, 5506.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable